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Article
Utilization of differentiated instruction in K-12 classrooms: a systematic literature review (2000–2022)
Differentiated instruction (DI) is a beneficial approach to addressing students’ diverse learning needs, abilities, and interests to ensure that each student has the opportunity to make academic progress. To a...
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Article
Open AccessIncreased knee torsional misalignment associated with femoral torsion is related to non-contact anterior cruciate ligament injury: a case–control study
Altered axial biomechanics of the knee are recognized as a risk factor for non-contact anterior cruciate ligament (ACL) injury. However, the relationship of knee and segmental torsion to non-contact ACL and co...
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Chapter and Conference Paper
Low-Light Image Enhancement Based on Mutual Guidance Between Enhancing Strength and Image Appearance
The existing low light image enhancement (LLIE) methods primarily aim at adjusting the overall brightness of the image, which are prone to produce the over-enhancement issue, such as over-exposure and edge hal...
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Article
Food Effect on the Pharmacokinetics of VC004, a Tropomyosin Receptor Kinase Inhibitor: A Randomized Crossover Trial in Healthy Chinese Subjects
VC004 is a novel next-generation tropomyosin receptor kinase (TRK) inhibitor that is approved for the treatment of advanced or metastatic NTRK fusion-positive solid tumors and abrogated the drug resistance of ...
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Article
Open AccessPyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice
Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testo...
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Article
Therapeutic drug monitoring of immune checkpoint inhibitors: based on their pharmacokinetic properties and biomarkers
As a new means of oncology treatment, immune checkpoint inhibitors (ICIs) can improve survival rates in patients with resistant or refractory tumors. However, there are obvious inter-individual differences in...
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Article
Effect of a moderate CYP3A inducer efavirenz on the pharmacokinetics of fuzuloparib: An open-label, fixed sequence study in Chinese healthy male subjects
To evaluate the potential drug-drug interaction (DDI), safety and tolerability of fuzuloparib co-administered with a moderate CYP3A inducer efavirenz in healthy male subjects. Eighteen healthy male subjects we...
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Chapter and Conference Paper
Secondary Frequency Regulation Control Strategy of Battery Energy Storage with Improved Consensus Algorithm
In order to improve the frequency stability of the microgrid, this paper proposes a two-layer strategy for secondary frequency modulation of battery energy storage based on an improved consensus algorithm. The...
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Article
Phase I study to evaluate of the gastric pH-dependent drug interaction between famitinib and the proton pump inhibitor omeprazole in healthy subjects
To evaluate the potential gastric pH-dependent drug-drug interaction (DDI), safety and tolerability of famitinib co-administered with omeprazole in healthy subjects. Twenty healthy subjects were enrolled in a ...
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Article
Open AccessFinancial toxicity in female patients with breast cancer: a national cross-sectional study in China
To quantify financial toxicity of female patients with breast cancer in China and investigate its factors and patients’ co** strategies.
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Article
Open AccessIcariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats
Diabetes mellitus (DM), a chronic metabolic disease, severely impairs male reproductive function. However, the underpinning mechanisms are still incompletely defined, and there are no effective strategies or m...
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Article
A CW, 94 GHz Second Harmonic Gyrotron with a Continuous Operation Solenoid Cooled by Water
Design and experimental results of a continuous wave (CW), 94 GHz second harmonic gyrotron with a 1.8 T continuous operation solenoid are presented. In order to reduce power consumption of the solenoid, a carb...
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Article
Open AccessSatisfaction of family members with inpatient psychiatric care and its correlates: a national survey in China
Measuring family members’ satisfaction with inpatient psychiatric care may help improve the quality of healthcare in psychiatric hospitals. This survey aimed to investigate the satisfaction of family members w...
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Article
Open AccessSatisfaction of psychiatric inpatients in China: clinical and institutional correlates in a national sample
Surveying patients’ satisfaction is essential to improve patient-centered care, however, studies on satisfaction and their correlates among psychiatric inpatients are rare in China. This study aimed to measure...
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Article
Trivalent chromium alleviates oleic acid induced steatosis in SMMC-7721 cells by decreasing fatty acid uptake and triglyceride synthesis
Trivalent chromium [Cr(III)] has been shown as an essential trace element for human health. Previous studies depict that Cr(III) plays important roles in maintaining normal glucose and lipid metabolism, wherea...
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Article
Open AccessRoles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion system
Hcp (hemolysin-coregulated protein) is considered a vital component of the functional T6SS (Type VI Secretion System), which is a newly discovered secretion system. Our laboratory has previously sequenced the ...
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Article
In vitro metabolism of bencycloquidium bromide and its inhibitory effects on human P450 isoenzymes: implication of CYP2D6, CYP2C19 and CYP3A4/5
Bencycloquidium bromide (BCQB) is a novel selective muscarinic M1/M3 receptor antagonist with potent therapeutic effects on rhinitis and chronic obstructive pulmonary disease. The metabolism of BCQB has been i...
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Article
In vivo and in vitro evidence of the sex-dependent pharmacokinetics and disposition of G004, a potential hypoglycemic agent, in rats
G004 is a novel sulfonylurea hypoglycemic drug which aimed at reducing macro- and micro-vascular complications as well as controlling glucose excursion in type 2 diabetes mellitus. The pharmacokinetics of G004...
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Article
Research on the effects of coordinate deformation on radial-axial ring rolling process by FE simulation based on in-process control
Radial-axial ring rolling process is an irreplaceable metal forming technology for manufacturing various seamless rings. However, during the process, there exists complex interaction of deformations in the rad...
