4 Result(s)
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Article
Open AccessHDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function. Currently, histone desu...
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Article
Open AccessThe UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation
Impaired protein N-glycosylation leads to the endoplasmic reticulum (ER) stress, which triggers adaptive survival or maladaptive apoptosis in renal tubules in diabetic kidney disease (DKD). Therapeutic strateg...
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Article
Open AccessBMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease
Tubulointerstitial fibrosis (TIF) is involved in the development of diabetic kidney disease (DKD). Transforming growth factor β1 (TGF-β1) is involved in the extensive fibrosis of renal tissue by facilitating t...
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Article
Open AccessMYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent
Heightened aerobic glycolysis and glutaminolysis are characteristic metabolic phenotypes in cancer cells. Neuroblastoma (NBL), a devastating pediatric cancer, is featured by frequent genomic amplification of M...
