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Open AccessB-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers
The key signature of cancer genomes is the accumulation of DNA mutations, the most abundant of which is the cytosine-to-thymine (C-to-T) transition that results from cytosine deamination. Analysis of The Cance...
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Open AccessFunctional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements
Estrogen forms a complex with the estrogen receptor (ER) that binds to estrogen response elements (EREs) in the regulatory region of estrogen-responsive genes and regulates their transcription. Sequence varian...
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Open AccessCo-modulated behavior and effects of differentially expressed miRNA in colorectal cancer
MicroRNAs (miRNAs) are short noncoding RNAs (approximately 22 nucleotides in length) that play important roles in colorectal cancer (CRC) progression through silencing gene expression. Numerous dysregulated miRNA...
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Article
Open AccessComprehensive analysis of microRNAs in breast cancer
MicroRNAs (miRNAs) are short noncoding RNAs (approximately 22 nucleotides in length) that play important roles in breast cancer progression by downregulating gene expression. The detailed mechanisms and biolog...
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Article
Open AccessGenetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development
Estrogen forms a complex with the estrogen receptor (ER) that binds to estrogen response elements (EREs) in the promoter region of estrogen-responsive genes, regulates their transcription, and consequently med...
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Article
Open AccessDiscovery and characterization of medaka miRNA genes by next generation sequencing platform
MicroRNAs (miRNAs) are endogenous non-protein-coding RNA genes which exist in a wide variety of organisms, including animals, plants, virus and even unicellular organisms. Medaka (Oryzias latipes) is a useful mod...
