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Open AccessComparative analysis of genetic risk scores for predicting biochemical recurrence in prostate cancer patients after radical prostatectomy
In recent years, Genome-Wide Association Studies (GWAS) has identified risk variants related to complex diseases, but most genetic variants have less impact on phenotypes. To solve the above problems, methods ...
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Article
Open AccessIntegrated analysis identifies GABRB3 as a biomarker in prostate cancer
Treatment failure following androgen deprivation therapy (ADT) presents a significant challenge in the management of advanced prostate cancer. Thus, understanding the genetic factors influencing this process c...
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Article
Open AccessTNFRSF13B is a potential contributor to prostate cancer
Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. However, the link between immunodeficiency and prostate cancer progressi...
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Article
Open AccessAssessment of factors associated with PSA level in prostate cancer cases and controls from three geographical regions
It is being debated whether prostate-specific antigen (PSA)-based screening effectively reduces prostate cancer mortality. Some of the uncertainty could be related to deficiencies in the age-based PSA cut-off ...
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Article
Open AccessOccupational noise exposure and its association with incident hyperglycaemia: a retrospective cohort study
Noise pollution is reported to be associated with diabetes, but few studies have elucidated the associations between noise frequency characteristics. We aimed to evaluate the relationships between different no...
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Article
Open AccessPolymorphism of nucleotide binding domain-like receptor protein 3 (NLRP3) increases susceptibility of total urinary arsenic to renal cell carcinoma
Our study showed that total urinary arsenic concentrations were positively correlated with renal cell carcinoma (RCC). Chronic inflammation is a key player in the development of RCC. This study explored the as...
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Article
Open AccessGenetic variants in the circadian rhythm pathway as indicators of prostate cancer progression
To determine the association between circadian pathway genetic variants and the risk of prostate cancer progression.
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Article
MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats
Defective renal salt and water excretion, together with increased salt intake, frequently contributes to hypertension. Recent studies indicate that Ste20 family kinases, such as proline-alanine-rich Ste20-rela...
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Article
Open AccessLower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipo...
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Article
Open AccessInduction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum
Apoptosis is an essential physiological process that controls many important biological functions. However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a my...
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Article
Open AccessUrinary melatonin-sulfate/cortisol ratio and the presence of prostate cancer: A case-control study
The circadian-related hormones, melatonin and cortisol, have oncostatic and immunosuppressive properties. This study examined the relationship between these two biomarkers and the presence of prostate cancer. ...
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Article
Open AccessGenetic variants in ultraconserved regions associate with prostate cancer recurrence and survival
Ultraconserved regions (UCRs) are DNA segments of longer than 200 bp in length that are completely conserved between human, rat, and mouse genomes. Recent studies have shown that UCRs are frequently located at...
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Article
Open AccessGenetic variants of the autophagy pathway as prognostic indicators for prostate cancer
Autophagy is a complex process of autodigestion in conditions of cellular stress and it might play an important role in the pathophysiology during carcinogenesis. We hypothesize that genetic variants of the au...
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Article
Open AccessGenetic variants in the Hippo pathway predict biochemical recurrence after radical prostatectomy for localized prostate cancer
While localized prostate cancer is potentially curative, many patients still show biochemical recurrence (BCR) after curative treatments such as radical prostatectomy (RP). The Hippo pathway has recently been ...
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Article
Open AccessRoad traffic noise frequency and prevalent hypertension in Taichung, Taiwan: A cross-sectional study
Epidemiological studies have reported the association between hypertension and exposure to road traffic noise, but the association between noise frequency characteristics is not clear. This study investigated ...
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Article
Genetic variations in TP53 binding sites are predictors of clinical outcomes in prostate cancer patients
Since the tumor protein p53 (TP53), a transcription factor, plays a crucial role in prostate cancer development and progression, we hypothesized that sequence variants in TP53 binding sites might affect clinic...
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Article
Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer
Molecular epidemiology studies have shown that vitamin D receptor (VDR) gene polymorphisms are associated with prostate cancer risk. However, the prognostic value of these polymorphisms on clinical outcomes in pr...
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Article
Open AccessThe roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice
Successful reproductive efforts require the establishment of a situation favorable for reproduction that requires integration of both behavior and internal physiological events. TR4 nuclear receptor is known t...
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Article
Open AccessHigh-frequency hearing loss, occupational noise exposure and hypertension: a cross-sectional study in male workers
The association between occupational noise exposure and hypertension is inconsistent because of an exposure bias caused by outer-ear measurements of noise levels among workers. This study used hearing loss val...
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Article
Open AccessGenetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development
Estrogen forms a complex with the estrogen receptor (ER) that binds to estrogen response elements (EREs) in the promoter region of estrogen-responsive genes, regulates their transcription, and consequently med...
