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Article
Open AccessZEB family is a prognostic biomarker and correlates with anoikis and immune infiltration in kidney renal clear cell carcinoma
Zinc finger E-box binding homEeobox 1 (ZEB1) and ZEB2 are two anoikis-related transcription factors. The mRNA expressions of these two genes are significantly increased in kidney renal clear cell carcinoma (KI...
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Article
Open AccessRegulatory controls of duplicated gene expression during fiber development in allotetraploid cotton
Polyploidy complicates transcriptional regulation and increases phenotypic diversity in organisms. The dynamics of genetic regulation of gene expression between coresident subgenomes in polyploids remains to b...
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Article
Open AccessExosomal LncRNA RP5-977B1 as a novel minimally invasive biomarker for diagnosis and prognosis in non-small cell lung cancer
Lung cancer is the leading cause of cancer-related deaths in the world. Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases. For lack of conveniently sensitive and specific biomarkers,...
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Article
Open AccessFast anther dehiscence status recognition system established by deep learning to screen heat tolerant cotton
From an economic perspective, cotton is one of the most important crops in the world. The fertility of male reproductive organs is a key determinant of cotton yield. Anther dehiscence or indehiscence directly ...
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Article
Open AccessGenome-wide identification, evolutionary estimation and functional characterization of two cotton CKI gene types
Casein kinase I (CKI) is a kind of serine/threonine protein kinase highly conserved in plants and animals. Although molecular function of individual member of CKI family has been investigated in Arabidopsis, litt...
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Article
Open AccessAn enhanced photosynthesis and carbohydrate metabolic capability contributes to heterosis of the cotton (Gossypium hirsutum) hybrid ‘Huaza Mian H318’, as revealed by genome-wide gene expression analysis
Heterosis has been exploited for decades in different crops due to resulting in dramatic increases in yield, but relatively little molecular evidence on this topic was reported in cotton.
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Article
Open AccessEfficient CRISPR/Cas9 mediated Pooled-sgRNAs assembly accelerates targeting multiple genes related to male sterility in cotton
Upland cotton (Gossypium hirsutum), harboring a complex allotetraploid genome, consists of A and D sub-genomes. Every gene has multiple copies with high sequence similarity that makes genetic, genomic and functio...
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Article
Open AccessReference genome sequences of two cultivated allotetraploid cottons, Gossypium hirsutum and Gossypium barbadense
Allotetraploid cotton species (Gossypium hirsutum and Gossypium barbadense) have long been cultivated worldwide for natural renewable textile fibers. The draft genome sequences of both species are available but t...
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Article
Promoters of Arabidopsis Casein kinase I-like 2 and 7 confer specific high-temperature response in anther
(1) We systematically analyze the promoter activities of AtCKLs in various tissues; (2) AtCKL2 and AtCKL7 were expressed in early developmental anthers under high temperature (HT) conditions; (3) AtMYB24 may func...
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Article
Open AccessCyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
The assembly of prereplicative complex (pre-RC) during G1 phase must be tightly controlled to sustain cell proliferation and maintain genomic stability. Mechanisms to prevent pre-RC formation in G2/M and S pha...
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Article
Open AccessSenescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway
Although targeted therapy and immunotherapy greatly improve the outcome of melanoma, drug resistance and low response rates still maintain the unsubstitutability of traditional chemotherapy. Cisplatin (CDDP) i...
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Article
Asymmetric subgenome selection and cis-regulatory divergence during cotton domestication
**anlong Zhang, Keith Lindsey and colleagues report a population genomic analysis of Upland cotton (Gossypium hirsutum) that identifies 93 potential domestication-sweep regions and 19 candidate loci for fiber-qua...
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Article
The Sophora Alopecuroid H + -PPase Gene SaVP1 Confers Multiple Abiotic Stress Tolerance in Arabidopsis
The physiological role of a vacuolar H+-PPase (SaVP1) from an eremophyte, Sophora alopecuroid, was evaluated through overexpressing in Arabidopsis. Overexpression of SaVP1 in Arabidopsis enhanced tolerance to dro...
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Article
Open AccessDefective pollen wall contributes to male sterility in the male sterile line 1355A of cotton
To understand the mechanisms of male sterility in cotton (Gossypium spp.), combined histological, biochemical and transcription analysis using RNA-Seq was carried out in the anther of the single-gene recessive ge...
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Article
Open AccessCotton cytochrome P450 CYP82D regulates systemic cell death by modulating the octadecanoid pathway
Plant oxylipins are derived from unsaturated fatty acids and play roles in plant growth and development as well as defence. Although recent studies have revealed that fatty acid metabolism is involved in syste...
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Article
Multiple shoots induction in wild cotton (Gossypium bickii) through organogenesis and the analysis of genetic homogeneity of the regenerated plants
Fertile plants were regenerated via organogenesis from cultures of Gossypium bickii Prokhanov cotyledonary nodes devoid of cotyledons. Cotyledonary nodes from 7-day-old seedlings yielded the maximum number of sho...
