560 Result(s)
within
Lin** Zhang
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
-
Article
HIV-1 subtype and second-receptor use
-
Article
Flexible style that encourages outcrossing
Despite the convenience of self-pollination (selfing) in flowering plants 1,2,3, the detrimental effects of inbreeding that follow repeated selfing3,4 have promoted strong natural selection for mating systems tha...
-
Article
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signalling proteins, including HER-2/ErbB2, Akt, Raf-1, Bcr-Abl and mutated p531,2,3,4,5,
-
Article
The changing face of HIV in China
HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread?
-
Article
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis
The membrane-bound tumour necrosis factor-related ligand TRAIL (also called TNFSF10 and Apo2L) is known to induce apoptosis or cell death in cancer cells but not in normal cells. With a view to develo** a wa...
-
Article
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
Recruitment of p53 binding protein 1 (53BP1) to double-strand DNA breaks is an important step in the cellular response to DNA damage. Here, the histone methyltransferase MMSET is shown to be responsible for lo...
-
Article
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Regulatory T (Treg) cells are an important immunosuppressive lymphocyte population implicated in peripheral tolerance and in the pathogenesis of autoimmunity and cancer. The mechanisms accounting for Treg cell ac...
-
Article
Open AccessSingle molecule detection from a large-scale SERS-active Au79Ag21 substrate
Detecting and identifying single molecules are the ultimate goal of analytic sensitivity. Single molecule detection by surface-enhanced Raman scattering (SM-SERS) depends predominantly on SERS-active metal sub...
-
Article
Open AccessTandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination
We describe a site-specific recombination-based tandem assembly (SSRTA) method for reconstruction of biological parts in synthetic biology. The system was catalyzed by Streptomyces phage φBT1 integrase, which bel...
-
Article
Bring safe sex to China
China's discomfort over discussing sex, and especially homosexuality, is a major problem when it comes to HIV, says a consortium of researchers in China.
-
Article
Open AccessThe oyster genome reveals stress adaptation and complexity of shell formation
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads ...
-
Article
ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors
Under stress conditions such as acute blood loss or chronic anaemia, glucocorticoids trigger self-renewal of early burst-forming unit–erythroid (BFU–E) progenitors in the spleen, however, the mechanism of gluc...
-
Article
Open AccessEnlarging photovoltaic effect: combination of classic photoelectric and ferroelectric photovoltaic effects
Converting light energy to electrical energy in photovoltaic devices relies on the photogenerated electrons and holes separated by the built-in potential in semiconductors. Photo-excited electrons in metal ele...
-
Article
Open AccessA facile method to align carbon nanotubes on polymeric membrane substrate
The alignment of carbon nanotubes (CNT) is the fundamental requirement to ensure their excellent functions but seems to be desolated in recent years. A facile method, hot-press combined with peel-off (HPPO), i...
-
Article
Development of an ultra-thin film comprised of a graphene membrane and carbon nanotube vein support
Graphene, exhibiting superior mechanical, thermal, optical and electronic properties, has attracted great interest. Considering it being one-atom-thick, and the reduced mechanical strength at grain boundaries,...
-
Article
Open AccessPositron acceleration in a hollow plasma channel up to TeV regime
Nowadays, human's understanding of the fundamental physics is somehow limited by the energy that our high energy accelerators can afford. Up to 4 TeV protons are realized in the Large Hadron Collider (LHC). Le...
-
Article
Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice
The role of bone marrow (BM) and BM-derived cells in radiation-induced acute gastrointestinal (GI) syndrome is controversial. Here we use bone marrow transplantation (BMT), total body irradiation (TBI) and abd...
-
Article
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Nicotinamide N-methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against diet-induced obesity by altering the availability of a...
-
Article
Open AccessMnO2 Nanorods Intercalating Graphene Oxide/Polyaniline Ternary Composites for Robust High-Performance Supercapacitors
New ternary composites of MnO2 nanorods, polyaniline (PANI) and graphene oxide (GO) have been prepared by a two-step process. The 100 nm-long MnO2 nanorods with a diameter ~20 nm are conformably coated with PANI ...
-
Article
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
Neddylation, the covalent attachment of ubiquitin-like protein Nedd8, of the Cullin-RING E3 ligase family regulates their ubiquitylation activity. However, regulation of HECT ligases by neddylation has not bee...
