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Article
Open AccessAssociation of birth weight with type 2 diabetes mellitus and the mediating role of fatty acids traits: a two-step mendelian randomization study
Observational studies have suggested an association between birth weight and type 2 diabetes mellitus, but the causality between them has not been established. We aimed to obtain the causal relationship betwee...
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Article
Open AccessGlobal epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis
Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) shares common pathophysiological mechanisms with type 2 diabetes, making them significant risk factors for type 2 ...
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Article
Open AccessInterindividual- and blood-correlated sweat phenylalanine multimodal analytical biochips for tracking exercise metabolism
In situ monitoring of endogenous amino acid loss through sweat can provide physiological insights into health and metabolism. However, existing amino acid biosensors are unable to quantitatively assess metabol...
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Article
Resonant four-photon photoemission from SnSe2(001)
High-order nonlinear multiphoton absorption is usually inefficient, but can be enhanced by designing resonant excitations between occupied and unoccupied energy levels. We conducted angle-resolved multi-photon...
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Article
Cancer-associated fibroblasts in papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) has a relatively good prognosis, yet there are some invasive PTC cases with worse clinicopathological features and poor outcome. Cancer-associated fibroblasts (CAFs) play an i...
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Article
Demonstration and operation of quantum harmonic oscillators in an AlGaAs-GaAs heterostructure
The quantum harmonic oscillator (QHO), one of the most important and ubiquitous model systems in quantum mechanics, features equally spaced energy levels or eigenstates. Here we present a new class of nearly i...
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Article
Peripheral white blood cell counts mediated the associations of sleep duration with atherosclerotic cardiovascular disease risk: a cross-sectional study of middle-aged and older Chinese
To investigate the associations between sleep duration and atherosclerotic cardiovascular disease (ASCVD) risk and the potential mechanism.
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Article
Open AccessAutophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling
Tumor progression requires the communication between tumor cells and tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are major components of stromal cells. CAFs contribute to metastasis proc...
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Targeted Integration of Complex Genetic Elements at Multi-Copy Loci by Golden Gate Assembly
Budding yeast Saccharomyces cerevisiae has become a model eukaryotic microorganism for targeted genomic manipulation due to its efficient homologous recombination. A few genomic loci, including rDNA, Delta, and T...
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Article
Open AccessOxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
Exposure to polycyclic aromatic hydrocarbons (PAHs) is related to decreased lung function. However, whether oxidative damage is involved in this relationship remains unclear. This study was aimed to explore th...
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Article
Open AccessRealizing nearly-free-electron like conduction band in a molecular film through mediating intermolecular van der Waals interactions
Collective molecular physical properties can be enhanced from their intrinsic characteristics by templating at material interfaces. Here we report how a black phosphorous (BP) substrate concatenates a nearly-f...
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Article
The floral organogenesis of Koelreuteria bipinnata and its variety K. bipinnata var. integrifolia (Sapindaceae): evidence of floral constraints on the evolution of monosymmetry
The floral organogenesis and anatomy of Koelreuteria bipinnata and its variety K. bipinnata var. integrifolia (Sapindaceae) has been investigated to clarify the identity of the two taxa in relation to other speci...
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Article
Optimizing the coordinated transcription of central xylose-metabolism genes in Saccharomyces cerevisiae
The efficient fermentation of xylose can improve biofuel production. We previously developed a two-stage transcriptional reprogramming (TSTR) strategy (including a glucose fermentation stage and a xylose ferme...
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Article
Construction, characterization and application of a genome-wide promoter library in Saccharomyces cerevisiae
Promoters are critical elements to control gene expression but could behave differently under various growth conditions. Here we report the construction of a genome-wide promoter library, in which each native ...
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Article
Systematic analysis of the maize cyclophilin gene family reveals ZmCYP15 involved in abiotic stress response
Cyclophilins (CYPs) belong to the immunophilin superfamily, having the peptidyl prolyl cis/trans isomerase activity that can catalyze the cis/trans isomerisation process of proline residues. Previous studies h...
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Article
Determination of Neomycin in Aquatic Products Using an Immunoaffinity Column Coupled to High-Performance Liquid Chromatography
Neomycin is widely used in veterinary medicine, while the confirmatory analysis of neomycin residues in aquatic samples has not been well identified. Here, in this study, an immunoaffinity chromatography (IAC)...
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Article
Isolation, characterization, and identification of proteins interfering with enzyme-linked immunosorbent assay of antibiotics in fish matrix
The interaction between some proteins and immune globulin has been confirmed as an important source of matrix interference with the immunoassay of fishery products, but detailed biochemical properties of these...
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Article
Development of a Nano-Gold Capillary Immunochromatographic Assay for Rapid and Semi-Quantitative Detection of Clenbuterol Residues
A capillary immunochromatographic assay (CICA) using colloidal gold-labeled monoclonal antibodies was developed for semi-quantitative detection of clenbuterol (CLE) in this paper. This novel system fabricated ...
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Article
Open AccessHexose enhances oligonucleotide delivery and exon skip** in dystrophin-deficient mdx mice
Carbohydrate-based infusion solutions are widely used in the clinic. Here we show that co-administration of phosphorodiamidate morpholino oligomers (PMOs) with glucose enhances exon-skip** activity in Duchen...
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Article
Nano-gold capillary immunochromatographic assay for parvalbumin
A novel non-instrumental bioanalysis based on colloidal-gold immunochromatography in a modified glass capillary was developed and named capillary immunochromatographic assay (CICA). In this report, glass capil...
