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Open AccessRetraction Note: MCM3AP-AS1/miR-876-5p/WNT5A axis regulates the proliferation of prostate cancer cells
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Open AccessPrednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques
Adeno-associated virus (AAV) vector gene therapy is a promising approach to treat rare genetic diseases; however, an ongoing challenge is how to best modulate host immunity to improve transduction efficiency a...
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Open AccessThe RNA demethylase ALKBH5 promotes the progression and angiogenesis of lung cancer by regulating the stability of the LncRNA PVT1
N6-methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in human cancer progression. However, the biological function of m6A methylation requires further st...
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Comprehensive 16S rDNA Sequencing and LC–MS/MS-Based Metabolomics to Investigate Intestinal Flora and Metabolic Profiles of the Serum, Hypothalamus and Hippocampus in p‑Chlorophenylalanine-Induced Insomnia Rats Treated with Lilium brownie
Gut microbiota homeostasis in the organism and insomnia have been reported to influence each other. In the study, a method of 16S rRNA gene sequencing combined with ultra-high performance liquid chromatography...
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Long Noncoding RNA LINC01347 Modulated Lidocaine-Induced Cytotoxicity in SH-SY5Y Cells by Interacting with hsa-miR-145-5p
Local anesthetics, including lidocaine (Lid), are widely used in clinical settings but new evidence suggested that they may induce strong neurological side-effects in human brains. In this work, we used an in ...
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Open AccessZebrafish xenograft model of human lung cancer for studying the function of LINC00152 in cell proliferation and invasion
Numerous studies have shown that long noncoding RNAs play important roles in human cancer progression. Although zebrafish xenografts have recently become a novel in vivo model for human cancer research, whethe...
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Open AccessRETRACTED ARTICLE: MCM3AP-AS1/miR-876-5p/WNT5A axis regulates the proliferation of prostate cancer cells
Although the fact that long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) is oncogenic in several cancers is well documented, very few researchers investigate its expression and function in prostate cancer.
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Open AccessCirc_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis
Researches validate that circular RNAs (circRNAs) are dysregulated in a variety of malignancies and play an important role in regulating the malignant phenotype of tumor cells. Nevertheless, the role of circ_0...
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Open AccessFTX contributes to cell proliferation and migration in lung adenocarcinoma via targeting miR-335-5p/NUCB2 axis
Extensive studies revealed that long non-coding RNAs (lncRNAs) could act as a regulator in tumors, including lung adenocarcinoma (LUAD). LncRNA FTX transcript, XIST regulator (FTX) has been reported to regulat...
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Open AccessOverexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells
Suppressor anaphase-promoting complex domain containing 2 (SAPCD2) is a novel gene playing important roles in the initiation, invasion, and metastasis of several malignancies. However, its role in colorectal c...
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Open Accesshsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway
Increasing studies indicated that circRNAs play critical roles in tumor progression. However, the roles and underlying mechanisms of circRNAs in gastric cancer (GC) remain largely unclear.
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miR-9*- and miR-124a-Mediated Switching of Chromatin Remodelling Complexes is Altered in Rat Spina Bifida Aperta
Neural tube defects (NTDs) are complex congenital malformations resulting from incomplete neurulation. Our previous work has demonstrated that motor and sensory neurons develop defectively in rat embryos with ...
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VEGF-Mediated Effects on Brain Microvascular Endothelial Tight Junctions and Transmigration of Breast Cancer Cells Across the Blood-Brain Barrier
Breast cancer spreads to the bones, lungs, brain and liver. While the mechanisms of breast metastasis to bones and lungs have been studied and characterized, there is little information about the molecular bas...