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Prednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques

Adeno-associated virus (AAV) vector gene therapy is a promising approach to treat rare genetic diseases; however, an ongoing challenge is how to best modulate host immunity to improve transduction efficiency a...

Alexander Kistner, Jessica A. Chichester, Lili Wang, Roberto Calcedo… in Gene Therapy (2024)