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  1. Article

    Open Access

    Prednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques

    Adeno-associated virus (AAV) vector gene therapy is a promising approach to treat rare genetic diseases; however, an ongoing challenge is how to best modulate host immunity to improve transduction efficiency a...

    Alexander Kistner, Jessica A. Chichester, Lili Wang, Roberto Calcedo… in Gene Therapy (2024)

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  2. Article

    Open Access

    Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration

    The development of liver-based adeno-associated virus (AAV) gene therapies is facing concerns about limited efficiency and durability of transgene expression. We evaluated nonhuman primates following intraveno...

    Jenny A. Greig, Kelly M. Martins, Camilo Breton… in Nature Biotechnology (2023)

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  3. Article

    Open Access

    Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

    Transmission-blocking vaccines have the potential to be key contributors to malaria elimination. Such vaccines elicit antibodies that inhibit parasites during their development in Anopheles mosquitoes, thus break...

    Brandon McLeod, Kazutoyo Miura, Stephen W. Scally, Alexandre Bosch… in Nature Communications (2019)

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  4. No Access

    Article

    Engineering and expression of a RhoA peptide against respiratory syncytial virus infection in plants

    A RhoA-derived peptide fused to carrier molecules from plants showed enhanced biological activity of in vitro assays against respiratory syncytial virus compared to the RhoA peptide alone or th...

    Benita Ortega-Berlanga, Konstantin Musiychuk, Yoko Shoji, Jessica A. Chichester… in Planta (2016)

  5. No Access

    Article

    Stabilization of HAC1 Influenza Vaccine by Spray Drying: Formulation Development and Process Scale-Up

    Stable vaccines with long shelf lives and reduced dependency on the cold chain are ideal for stockpiling and rapid deployment during public emergencies, including pandemics. Spray drying is a low-cost process ...

    Changcheng Zhu, Yoko Shoji, Scott McCray, Michael Burke… in Pharmaceutical Research (2014)

  6. No Access

    Chapter

    Hairy Roots as a Vaccine Production and Delivery System

    Prevention of infectious diseases by vaccination is often limited because of the lack of safe, effective, and accessible vaccines. Traditional vaccines are expensive and require special conditions for storage,...

    Marina Skar**skaia, Karen Ruby, Adriana Araujo… in Biotechnology of Hairy Root Systems (2013)

  7. Article

    Open Access

    Plant-produced transmission blocking Plasmodium falciparum Pfs25 subunit and VLP based vaccine candidates

    Konstantin Musivchuk, Vadim Mett, Louis Casta, Christine E Farrance… in Malaria Journal (2012)

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