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  1. No Access

    Chapter

    Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor

    Cancer is a complex syndrome of diseases characterized by the increased abundance of cells that disrupts the normal tissue architecture within an organism. Defining one universal mechanism underlyi...

    Lili Yamasaki in Cell Cycle Regulation (2006)

  2. No Access

    Article

    Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1

    Elzbieta H Wloga, Vittoria Criniti, Roderick T. Bronson… in Nature Cell Biology (2004)

  3. No Access

    Article

    A dynamic switch in Rb+/− mediated neuroendocrine tumorigenesis

    Rb+/− mice develop a complex spectrum of neuroendocrine tumors on a mixed genetic (129Sv × C57BL/6) background. To understand how the 129Sv and C57BL/6 contributions affect Rb+/− tumorigenesis, we serially backcr...

    Sandra W Leung, Elzbieta H Wloga, Alejandro F Castro, Thao Nguyen… in Oncogene (2004)

  4. No Access

    Chapter

    Role of the RB Tumor Suppressor in Cancer

    Apart from their coordinated inactivation by DNA tumor viral oncoproteins, the pRB and p53 tumor suppressor pathways were not known to be connected ten years ago. Within the last decade, our appreciation of ho...

    Lili Yamasaki in Signal Transduction in Cancer (2003)

  5. No Access

    Article

    Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

    Mutation of the retinoblastoma tumour-suppressor gene (RB) leads to the deregulation of many proteins and transcription factors that interact with the retinoblastoma gene product (pRB), including members of th...

    Lili Yamasaki, Roderick Bronson, Bart O. Williams, Nicholas J. Dyson… in Nature Genetics (1998)