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  1. No Access

    Article

    TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI

    Intermittent hypoxia (IH) is the primary pathological manifestation of obstructive sleep apnea (OSA) and the main cause of OSA-induced cognitive impairment. Hippocampal neurons are considered to be critical ce...

    Yinpei Huang, Zhili Liu, **n Wang, Yaoxu Li, Lian Liu, Bing Li in Neurochemical Research (2023)

  2. No Access

    Article

    Adenine base-editing-mediated exon skip** induces gene knockout in cultured pig cells

    Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9, Adenine base editor (ABE) convert single A·T pairs to G·C pairs in the genome without generating DNA doubl...

    **ang-xing Zhu, Jia-sheng Pan, Tao Lin, Ye-cheng Yang… in Biotechnology Letters (2022)

  3. No Access

    Article

    Application of the modified cytosine base-editing in the cultured cells of bama minipig

    Bama minipig is a unique miniature swine bred from China. Their favorable characteristics include delicious meat, strong adaptability, tolerance to rough feed, and high levels of stress tolerance. Unfavorable ...

    Jia-sheng Pan, Zi-sheng Lin, Jian-cong Wen, Jian-feng Guo… in Biotechnology Letters (2021)

  4. No Access

    Article

    Efficient CRISPR/Cas9-mediated gene editing in Guangdong small-ear spotted pig cells using an optimized electrotransfection method

    Guangdong Small-ear Spotted (GDSS) pigs are a pig breed native to China that possesses unfortunate disadvantages, such as slow growth rate, low lean-meat percentage, and reduced feed utilization. In contrast t...

    Yan-yan Wei, Qun-mei Zhan, **ang-xing Zhu, Ai-fen Yan, Juan Feng… in Biotechnology Letters (2020)

  5. Article

    Open Access

    N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer

    N6-methyladenosine (m6A) is the most common epigenetic RNA modification with essential roles in cancer progression. However, roles of m6A and its regulator METTL3 on non-coding RNA in gastric cancer are unknown. ...

    Yiting Sun, Song Li, Wenbin Yu, Zeyi Zhao, **g Gao, Cheng Chen… in Cell Death & Disease (2020)

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  6. No Access

    Article

    IP10, KC and M-CSF Are Remarkably Increased in the Brains from the Various Strains of Experimental Mice Infected with Different Scrapie Agents

    Activation of inflammatory cells and upregulations of a number of cytokines in the central nervous system (CNS) of patients with prion diseases are frequently observed. To evaluate the potential changes of som...

    Jia Chen, Cao Chen, Chao Hu, Lian Liu, Ying **a, Lin Wang, Wei Yang… in Virologica Sinica (2020)

  7. Article

    Open Access

    Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy

    Ultraviolet radiation is markedly increased because of pollution and the depletion of the stratospheric ozone layer. Excessive exposure to sunlight can negatively affect the skin, resulting in sunburn, photo-a...

    Dan Hao, **ang Wen, Lian Liu, Lian Wang, **anli Zhou, Yanmei Li… in Cell Death & Disease (2019)

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  8. No Access

    Article

    The Neuroprotective Roles of Sonic Hedgehog Signaling Pathway in Ischemic Stroke

    Ischemic stroke is characterized by high morbidity, mortality and disability rate worldwide. Because of its complexity in pathogenesis and lack of effective therapeutic strategies and drugs, great breakthrough...

    Lian Liu, Bo Zhao, **aoxing **ong, Zhongyuan **a in Neurochemical Research (2018)

  9. No Access

    Article

    Map** the transcription repressive domain in the highly conserved human gene hnulp1

    HNULP1, a new member of the basic helixloop-helix transcription factors, contains a DUF654 domain in its C-terminus and is highly conserved from Drosophilae, yeast, zebrafish to mouse. The function of this motif,...

    Yuequn Wang, Lian Liu, Zhenyu Cai, Yongqing Li… in Frontiers of Biology in China (2008)