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Article
Update on lacrimal apparatus dysfunction associated with differentiated thyroid cancer after I-131 therapy
The most prevalent lacrimal apparatus dysfunctions associated with differentiated thyroid cancer(DTC) after I-131 therapy are dry eye and nasolacrimal duct obstruction(NLDO), leading to ocular discomfort and l...
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Article
Mitochondrial Uncoupling Protein-2 Ameliorates Ischemic Stroke by Inhibiting Ferroptosis-Induced Brain Injury and Neuroinflammation
Ischemic stroke is a devastating disease in which mitochondrial damage or dysfunction substantially contributes to brain injury. Mitochondrial uncoupling protein-2 (UCP2) is a member of the UCP family, which r...
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Article
Open AccessFMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury
Depression frequently occurs following traumatic brain injury (TBI). However, the role of Fibromodulin (FMOD) in TBI-related depression is not yet clear. Previous studies have suggested FMOD as a potential key...
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Article
Open AccessClarification of the infection pattern of Xanthomonas citri subsp. citri on citrus fruit by artificial inoculation
Citrus canker is a significant bacterial disease caused by Xanthomonas citri subsp. citri (Xcc) that severely impedes the healthy development of the citrus industry. Especially when citrus fruit is infected by Xc...
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Article
Deoxynivalenol Damages Corneal Epithelial Cells and Exacerbates Inflammatory Response in Fungal Keratitis
Fungal keratitis (FK) is a kind of infectious keratopathy with a high rate of blindness worldwide. Deoxynivalenol (DON) has been proven to have multiple toxic effects on humans and animals.
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Article
Reduced graphene oxide/polyurethane composite sponge fabricated by dual-templates method for piezoresistive pressure sensor
Wearable sensors with highly flexible and sensitive characteristics have attracted research interests in the promising field of electronic skin, health monitoring, and soft robotics. However, the develo** of...
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Article
Circadian Regulation of the Lactate Metabolic Kinetics in Mice Using the [1H-13C]-NMR Technique
Lactate is not only the energy substrate of neural cells, but also an important signal molecule in brain. In modern societies, disturbed circadian rhythms pose a global challenge. Therefore, exploring the infl...
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Article
Expression patterns of HDA9, HDA6 and FLD in Chinese cabbage (Brassica rapa L. ssp. pekinensis) under different photoperiods and their protein interactions
Histone deacetylases (HDACs) are important regulators that participate in plant growth and development. HISTONE DEACETYLASE 9 (HDA9), HISTONE DEACETYLASE 6 (HDA6) and FLOWERING LOCUS D (FLD) are reported to be in...
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Article
An unexpected contribution of higher education towards the innovations: the moderate role of green technology
Understanding how environmental restrictions affect the relationship between economic stability and unbalanced technical innovation is crucial for optimizing environmental and financial policy frameworks in de...
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Article
TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI
Intermittent hypoxia (IH) is the primary pathological manifestation of obstructive sleep apnea (OSA) and the main cause of OSA-induced cognitive impairment. Hippocampal neurons are considered to be critical ce...
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Article
Open AccessThe TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation
The Mulibrey (Muscle–liver–brain–eye) nanism caused by loss-of-function variants in TRIM37 gene is an autosomal recessive disorder characterized by severe growth failure and constrictive pericarditis. These patie...
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Article
Predicting the Rapid Improvement of Papilledema After Stenting in Idiopathic Intracranial Hypertension
This study aimed to identify predictors of rapid improvement of papilledema after stenting and develop a simple preintervention scale.
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Article
From Diabetes to Diabetic Complications: Role of Autophagy
Diabetes and its complications reduce quality of life and are life-limiting. At present, diabetes treatment consists of hypoglycemic agents to control blood glucose and the use of insulin-sensitizing drugs to ...
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Article
Effect of human umbilical cord mesenchymal stem cell exosomes on aerobic metabolism of human retinal pigment epithelial cells
To investigate the effect of exosomes secreted by human umbilical cord mesenchymal stem cells (HUCMSC-Exo) on aerobic metabolism of cobalt chloride (CoCl2)-induced oxidative damage in the human retinal pigment ep...
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Article
Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skip**
Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9 and cytosine base editing (CBE) technologies, adenine base editing (ABE) shows better safety and accuracy i...
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Article
Phytoplanktonic biogeography in the subtropical coastal waters, East China Sea along intensive anthropogenic stresses: roles of environmental versus spatial factors
Understanding the relative roles of local environmental effects and spatial effects on phytoplankton community is of essential importance to study the biogeography of them at regional scale. However, the deter...
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Article
High prevalence and risk factors for osteoporosis in 1839 patients with systemic sclerosis: a systematic review and meta-analysis
Osteoporosis is prevalent in patients with systemic sclerosis (SSc). Updated evidence is required to complement the previous systematic review on this topic to provide best practices. This systematic review an...
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Article
Open AccessInferring router ownership based on the classification of intra- and inter-domain links
Research on router ownership inference is central to many Internet studies, such as network failure diagnosis, network boundary identification, network resilience assessment, and inter-domain congestion detect...
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Article
Investigation on the superconductivity of Nb3Al by Zn do** and the effect of multi-RHQT process on the superconductivity of Nb3(Al1-xZnx)
Nb3(Al1–xZnx) (x = 0–0.05) wires were obtained after single rapid heating, quenching and low temperature transformation (single-RHQT) process. It is found that Zn element can make crystal plane diffraction peaks ...
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Article
Open AccessDevelopment of a nomogram for predicting 90-day mortality in patients with sepsis-associated liver injury
The high mortality rate in sepsis patients is related to sepsis-associated liver injury (SALI). We sought to develop an accurate forecasting nomogram to estimate individual 90-day mortality in SALI patients. D...
