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Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus
Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological diversity. However, research on its phages is currently limited. In this study, we isolated a novel double-stranded ...
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Open AccessMir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Ferritinophagy-mediated ferroptosis plays a crucial role in fighting pathogen aggression. The long non-coding RNA Mir22hg is involved in the regulation of ferroptosis and aberrantly overexpression in lipopolys...
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Open AccessEnhancing efficiency of protein language models with minimal wet-lab data through few-shot learning
Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Pre-trained protein language models have achieved state-of-the-art performance in predicting protein fitness w...
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Reliable biological and multi-omics research through biometrology
Metrology is the science of measurement and its applications, whereas biometrology is the science of biological measurement and its applications. Biometrology aims to achieve accuracy and consistency of biolog...
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Constantly optimized mean teacher for semi-supervised 3D MRI image segmentation
The mean teacher model and its variants, as important methods in semi-supervised learning, have demonstrated promising performance in magnetic resonance imaging (MRI) data segmentation. However, the superior p...
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Pulpwood holocellulose model transfer based on screening with consistent and stable signals algorithm
In this study, in order to realize the sharing of the near-infrared analysis model of holocellulose between three spectral instruments of the same type, 84 pulp samples and their content of holocellulose were ...
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The superior detection rate of total-body [68Ga]Ga-PSMA-11 PET/CT compared to short axial field-of-view [68Ga]Ga-PSMA-11 PET/CT for early recurrent prostate cancer patients with PSA < 0.2 ng/mL after radical prostatectomy
[68Ga]Ga-PSMA PET imaging has been extensively utilized for the detection of biochemical recurrence (BCR) in prostate cancer. However, the detection rate declines to merely 10–40% when PSA levels are < 0.2 ng/mL ...
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PDE3B regulates KRT6B and increases the sensitivity of bladder cancer cells to copper ionophores
Cuproptosis is a new Cu-dependent programmed cell death manner that has shown regulatory functions in many tumor types, however, its mechanism in bladder cancer remains unclear. Here, we reveal that Phosphodie...
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Development of optimized functional clove fortified probiotic yoghurt
We focused on assessing the antimicrobial effects of functional yoghurts supplemented with clove and probiotics. The formulation of aqueous clove extract (ACE) incorporated with probiotic yoghurt (Streptococcus t...
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Open AccessFeasibility of CT attenuation values in distinguishing acute ischemic stroke, old cerebral infarction and leukoaraiosis
This study aimed to investigate the feasibility of using computed tomography (CT) attenuation values to differentiate hypodense brain lesions, specifically acute ischemic stroke (AIS) from asymmetric leukoarai...
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Optimization of geometry parameters and cutting parameters of threading tool based on neural network prediction model for chip flow angle of single-edged oblique cutting
A method for optimizing the threading tool’s geometry and cutting parameters based on a neural network prediction model for chip flow angle (CFA) of single-edged oblique cutting is proposed. Firstly, four cont...
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Open AccessExosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to oral potentially malignant disorders. Abnormal fibroblast differentiation leading to d...
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Open AccessEngineering ZrO2–Ru interface to boost Fischer-Tropsch synthesis to olefins
Understanding the structures and reaction mechanisms of interfacial active sites in the Fisher-Tropsch synthesis reaction is highly desirable but challenging. Herein, we show that the ZrO2-Ru interface could be e...
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Open AccessIntegration analysis of transcriptome and proteome profiles brings new insights of somatic embryogenesis of two eucalyptus species
Somatic embryogenesis (SE) is recognized as a promising technology for plant vegetative propagation. Although previous studies have identified some key regulators involved in the SE process in plant, our knowl...
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Open AccessResearch on coal-rock identification method and data augmentation algorithm of comprehensive working face based on FL-Segformer
Coal-rock interface identification technology was pivotal in automatically adjusting the shearer’s cutting drum during coal mining. However, it also served as a technical bottleneck hindering the advancement o...
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Correction: Lp bounds for Stein’s spherical maximal operators
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Open AccessSex-Specific Entorhinal Cortex Functional Connectivity in Cognitively Normal Older Adults with Amyloid-β Pathology
Sex and apolipoprotein E (APOE) genotype have been shown to influence the risk and progression of Alzheimer’s disease (AD). However, the impact of these factors on the functional connectivity of the entorhinal...
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DNA demethylase Tet2 promotes the terminal maturation of natural killer cells
The cytotoxicity feature to eliminate malignant cells makes natural killer (NK) cells a candidate for tumor immunotherapy. However, this scenario is currently hampered by inadequate understanding of the regula...
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Proteomics identifies hypothermia induced adiponectin protects corneal endothelial cells via AMPK mediated autophagy in phacoemulsification
To explore the molecular mechanism underlying the protective effect of hypothermic perfusion on the corneal endothelium during phacoemulsification.
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Elite GA-based feature selection of LSTM for earthquake prediction
Earthquake magnitude prediction is an exceptionally challenging task that has been explored through various machine learning approaches. However, the development of prediction models is hindered by redundant f...
