110 Result(s)
within
Li-yuan **e
Life Sciences
English
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Article
Clpf encodes pentatricopeptide repeat protein (PPR5) and regulates pink flesh color in watermelon (Citrullus lanatus L.)
The gene controlling pink flesh in watermelon was finely mapped to a 55.26-kb region on chromosome 6. The prime candidate gene, Cla97C06G122120 (ClPPR5), was identified through forward genetics.
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Article
Open AccessMenstrual blood-derived mesenchymal stem cells combined with collagen I gel as a regenerative therapeutic strategy for degenerated disc after discectomy in rats
Annulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent disc degeneration following discectomy. Stem cell-based tissue engineering offers a promising a...
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Open AccessCircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, th...
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Discovery of novel Akt1 inhibitors by an ensemble-based virtual screening method, molecular dynamics simulation, and in vitro biological activity testing
Akt1, as an important member of the Akt family, plays a controlled role in cancer cell growth and survival. Inhibition of Akt1 activity can promote cancer cell apoptosis and inhibit tumor growth. Therefore, in...
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Genome-wide identification and analysis of the evolution and expression pattern of the SBP gene family in two Chimonanthus species
Chimonanthus praecox and Chimonanthus salicifolius are closely related species that diverged approximately six million years ago. While both C. praecox and C. salicifolius could withstand brief periods of low tem...
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Open AccessThe novel developed microsatellite markers revealed potential hybridization among Cymbidium species and the interspecies sub-division of C. goeringii and C. ensifolium
Orchids (Cymbidium spp.) exhibit significant variations in floral morphology, pollinator relations, and ecological habitats. Due to their exceptional economic and ornamental value, Cymbidium spp. have been commer...
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Open AccessComparative proteomic profiling of plasma exosomes in lung cancer cases of liver and brain metastasis
Metastases within liver or the brain are the most common causes of mortality from lung cancer (LC). Predicting liver or brain metastases before having evidence from imaging of the tumors is challenging but imp...
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Genome-wide identification and analysis of MIKC-type MADS-box genes expression in Chimonanthus salicifolius
MIKC type MADS-box transcription factors are one of the largest gene families and play a pivotal role in flowering time and flower development. Chimonanthus salicifolius belongs to the family Calycanthaceae and h...
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Open AccessInhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury
Cerebral ischemia-reperfusion injury (CIRI) is the main cause leading to high mortality and neurological disability in patients with cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Our previous study fo...
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Open AccessRetraction Note: Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2/ NQO1 axis via downregulating miR-450b-5p
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Open AccessHuman menstrual blood-derived stem cells reverse sorafenib resistance in hepatocellular carcinoma cells through the hyperactivation of mitophagy
Sorafenib is a first-line drug targeting the RTK-MAPK signalling pathway used to treat advanced hepatocellular carcinoma (HCC). However, tumour cells readily develop sorafenib resistance, limiting long-term th...
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Open AccessLegacy of Hongxi Su: Pioneer of Chinese Cardiosurgery
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Open AccessEBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma
Epstein–Barr virus (EBV) was the first oncogenic virus identified in humans. It is primarily associated with multiple lymphoid and epithelial cancers, including nasopharyngeal carcinoma (NPC). However, its ass...
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Open AccessGenetic testing enables a precision medicine approach for nephrolithiasis and nephrocalcinosis in pediatrics: a single-center cohort
Hereditary factors are the main cause of pediatric nephrolithiasis (NL)/nephrocalcinosis (NC). We summarized the genotype–phenotype correlation of hereditary NL/NC in our center, to evaluate the role of geneti...
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Article
LINC00313 facilitates osteosarcoma carcinogenesis and metastasis through enhancing EZH2 mRNA stability and EZH2-mediated silence of PTEN expression
Osteosarcoma is one of the five leading causes of cancer death among all pediatric malignancies. Recent advances in non-coding RNAs suggested that many long noncoding RNAs (lncRNAs) are dysregulated in cancer ...
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Article
Open AccessThe circadian clock ticks in plant stress responses
The circadian clock, a time-kee** mechanism, drives nearly 24-h self-sustaining rhythms at the physiological, cellular, and molecular levels, kee** them synchronized with the cyclic changes of environmenta...
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Article
AKT1, HAK5, SKOR, HKT1;5, SOS1 and NHX1 synergistically control Na+ and K+ homeostasis in sugar beet (Beta vulgaris L.) seedlings under saline conditions
Soil salinity is a growing problem for agricultural productivity worldwide. Our previous studies showed that tetraploid cultivar exhibited more tolerant to salinity than diploid one in sugar beet (Beta vulgaris L...
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Protocol
Circadian Rhythm: Phase Response Curve and Light Entrainment
The circadian clock responds to light signals and therefore participates in the plant’s daily response to light. The phase response curve (PRC) is typically used in the study of chronobiology to detect the eff...
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Protocol
Measurement of Luciferase Rhythms in Soybean Hairy Roots
Firefly luciferase is widely used as a bioluminescence reporter, which is simple, high signal-to-noise ratio and especially suitable for the long-term analysis of circadian clock-regulated gene expression. Her...
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Article
Open AccessThe thiol-disulfide exchange activity of AtPDI1 is involved in the response to abiotic stresses
Arabidopsis protein disulfide isomerase 1 (AtPDI1) has been demonstrated to have disulfide isomerase activity and to be involved in the stress response. However, whether the anti-stress function is directly rela...
