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    Article

    Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure

    Programmed cell death (PCD), including apoptosis, apoptotic necrosis, and pyroptosis, is involved in various organ dysfunction syndromes. Recent studies have revealed that a substrate of caspase-3, gasdermin E...

    Wan-feng Xu, Quan Zhang, Chu-jie Ding, Hui-yong Sun, Yuan Che… in Acta Pharmacologica Sinica (2021)

  2. Article

    Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair

    The use of ginseng extract as an adjuvant for cancer treatment has been reported in both animal models and clinical applications, but its molecular mechanisms have not been fully elucidated. Mitomycin C (MMC),...

    Min Zhao, Dan-dan Wang, Yuan Che, Meng-qiu Wu, Qing-ran Li… in Acta Pharmacologica Sinica (2018)

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  3. Article

    Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice

    In the penumbra after focal cerebral ischemia, an increase of protease Omi is linked to a decrease of Hs1-associated protein X-1 (Hax-1), a protein belonging to the Bcl-2 family. In this study we investigated ...

    Jia-yuan Wu, Mei Li, Li-juan Cao, Mei-ling Sun, Dong Chen… in Acta Pharmacologica Sinica (2015)

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  4. Article

    Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats

    To investigate the potential interactive effects of a high-fat diet (HFD) and valproic acid (VPA) on hepatic steatosis and hepatotoxicity in rats.

    Li-fang Zhang, Ling-sheng Liu, **ao-man Chu, … in Acta Pharmacologica Sinica (2014)

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