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  1. No Access

    Article

    A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model

    Prostate cancer (PCa) is the second most prevalent malignancy among men worldwide. The aberrant activation of androgen receptor (AR) signaling has been recognized as a crucial oncogenic driver for PCa and AR a...

    **n-yue Wang, **n Chai, Lu-hu Shan, **ao-hong Xu, Lei Xu… in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure

    Programmed cell death (PCD), including apoptosis, apoptotic necrosis, and pyroptosis, is involved in various organ dysfunction syndromes. Recent studies have revealed that a substrate of caspase-3, gasdermin E...

    Wan-feng Xu, Quan Zhang, Chu-jie Ding, Hui-yong Sun, Yuan Che… in Acta Pharmacologica Sinica (2021)