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Article
Numerical Study on the Influence of the Width of the SBM Disc Cutter on Rock Breaking
The study of the rock-breaking pattern of shaft boring machine (SBM) cutters is the basis for cutter design. In order to reveal the influence of the cutter blade width on the rock-breaking effect, this study e...
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Article
Open AccessIntegrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells
Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type of noncoding RNAs,...
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Article
Damage evolution and fragmentation behavior of pyramid cut blasting under uniaxial compression
Pyramid cut blasting is an essential form of inclined hole cut blasting, but the in-situ stress effect of pyramid cut blasting is rarely studied. Based on the research background of pyramid cut blasting in a d...
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Article
Open AccessGenotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response
The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting additional roles for this kinase. Here, we showed that the...
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Article
Open AccessEffects of different growth temperatures on growth, development, and plastid pigments metabolism of tobacco (Nicotiana tabacum L.) plants
Temperature remarkably affects the growth and metabolism of plants. Tobacco is an important cash crop, and the long-term effects of different growth temperatures (18.5, 23.5 and 28.5 °C, daily average) on grow...
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Article
Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities
CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion. CD97 (EGF1-5) is a ...
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Article
Open AccessA novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells
Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatmen...
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Article
Interaction of human serum albumin with 10-hydroxycamptothecin: spectroscopic and molecular modeling studies
In this work, fluorescence spectroscopy in combination with circular dichroism spectroscopy and molecular modeling was employed to investigate the binding of 10-hydroxycamptothecin (HCPT) to human serum albumi...
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Article
Interaction of Human Serum Albumin with Indomethacin: Spectroscopic and Molecular Modeling Studies
In this work, the interaction between indomethacin (IM) and human serum albumin (HSA) under simulative physiological conditions was investigated by the methods of fluorescence spectroscopy, circular dichroism ...
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Article
Nonlinear Landau-Zener tunneling of Bose-Einstein condensate in a spatially magnetic modulated trap
We study tunneling of a Bose-Einstein condensates confined in a effective double-well potential (a single well with a spatially magnetic modulated scattering length, actually), called pseudo double-well trap, ...
