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Article
Open AccessA chromosome-level genome assembly for the Silkie chicken resolves complete sequences for key chicken metabolic, reproductive, and immunity genes
A set of high-quality pan-genomes would help identify important genes that are still hidden/incomplete in bird reference genomes. In an attempt to address these issues, we have assembled a de novo chromosome-l...
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Article
Tubular TMEM16A promotes tubulointerstitial fibrosis by suppressing PGC-1α-mediated mitochondrial homeostasis in diabetic kidney disease
Tubulointerstitial fibrosis (TIF) plays a crucial role in the progression of diabetic kidney disease (DKD). However, the underlying molecular mechanisms remain obscure. The present study aimed to examine wheth...
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Article
Disrupted Brain Network Topology in Drug-naïve Essential Tremor Patients with and Without Depression
This study was carried out to investigate brain functional connectome and its potential relationships with the disease severity and emotion function in patients with essential tremor with and without depressiv...
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Article
A compound heterozygous PINK1-associated juvenile Parkinson’s disease with pregnancy in Chinese
PINK1 mutations are the second most common cause of recessive, early-onset Parkinson’s disease (EOPD), of which 15% are cases of juvenile PD. PD is a progressive neurological disease that primarily affects middle...
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Article
Altered spontaneous brain activity in essential tremor with and without resting tremor: a resting-state fMRI study
Essential tremor with resting tremor (rET) often exhibits severer clinical features and more extensive functional impairment than essential tremor without resting tremor (ETwr). However, the pathophysiology of...
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Article
Patterns of intrinsic brain activity in essential tremor with resting tremor and tremor-dominant Parkinson’s disease
The clinical pictures of essential tremor (ET) with resting tremor (rET) and tremor-dominant Parkinson’s disease (tPD) are often quite mimic at the early stage, current approaches to the diagnosis and treatmen...
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Article
Erbium YAG laser and diode laser applications for the second phase of implant surgery: a comparison of clinical outcomes
This study assessed the clinic outcomes of erbium: yttrium/aluminum/garnet (Er:YAG) laser and diode laser use in second phase of implant surgery.
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Article
Long-term low-dose morphine for patients with moderate cancer pain is predominant factor effecting clinically meaningful pain reduction
Patients with cancer often experience pain that affects their daily activities and quality of life. The analgesic ladder recommended by the World Health Organization has proved insufficient for many, and its s...
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Article
Open AccessEffects of different growth temperatures on growth, development, and plastid pigments metabolism of tobacco (Nicotiana tabacum L.) plants
Temperature remarkably affects the growth and metabolism of plants. Tobacco is an important cash crop, and the long-term effects of different growth temperatures (18.5, 23.5 and 28.5 °C, daily average) on grow...
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Article
Open AccessMonolithically integrated stretchable photonics
Mechanically stretchable photonics provides a new geometric degree of freedom for photonic system design and foresees applications ranging from artificial skins to soft wearable electronics. Here we describe t...
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Article
Assembly sequence planning considering the effect of assembly resources with a discrete fireworks algorithm
Assembly sequence planning plays the great role in the assembly process of products, because the quality of the assembly sequence directly influences the feasibility, cost, and the time of the assembly process...
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Article
Genetic analysis of FGF20 in Chinese patients with Parkinson’s disease
Sequence variants in fibroblast growth factor 20 (FGF20) have been reported to be associated with Parkinson’s disease (PD). We genotyped the rs591323 variant in a total of 2220 Han Chinese subjects, including ...
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Article
Frequency characteristics and far-field effect of gravity perturbation before earthquake
We used high-pass filtering and the Fourier transform to analyze tidal gravity data prior to five earthquakes from four superconducting gravity stations around the world. A stable gravitational perturbation si...
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Article
Genetic association study between RIT2 and Parkinson’s disease in a Han Chinese population
Recent several meta-analyses and certain case–control studies suggested that the Ras-like without CAAX 2 (RIT2) rs12456492 increased the risk of Parkinson’s disease (PD) in Asian and Caucasian populations. Howeve...
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Article
Open AccessKnowledge, attitudes, and influencing factors of cancer patients toward approving advance directives in China
Many cancer patients do not have advance directives (ADs), which may lead to unwanted excessive or aggressive care when patients have lost decision-making capacity. The aim of this study was to investigate kno...
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Article
Association of three candidate genetic variants in RAB7L1/NUCKS1, MCCC1 and STK39 with sporadic Parkinson’s disease in Han Chinese
Previous studies identified that polymorphisms RAB7L1/NUCKS1 rs823118, MCCC1 rs12637471 and STK39 rs1955337 to be the risk loci for Parkinson’s disease (PD) in a Caucasian population. However, the characteristics...
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Article
The Attitude of Oncology Physicians and Nurses to the Acceptance of New Drugs for Gene Therapy
With the efficacy of gene therapy verified in phase III trials, cancer patients will consider whether to accept gene therapy sooner or later. The purpose of this study is to investigate the attitudes of oncolo...
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Article
The reaction of o-hydroxybenzyl alcohol with phenyl isocyanate in polar solvents
The reaction of o-hydroxybenzyl alcohol with phenyl isocyanate has been investigated in different polar solvents with in situ FT-IR. The rate constants for the reactions of the phenolic hydroxyl group and the ali...
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Article
Different attitudes of oncology clinicians toward truth telling of different stages of cancer
To investigate different attitudes of oncology clinicians toward whether and how to disclose diagnosis to patients with different stages of cancer.
