245 Result(s)
within
Li**g Du
Life Sciences
Biotechnology
Microbial Genetics and Genomics
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Article
Open AccessBacteriocins attenuate Listeria monocytogenes–induced intestinal barrier dysfunction and inflammatory response
Bacteriocins have the potential to effectively improve food-borne infections or gastrointestinal diseases and hold promise as viable alternatives to antibiotics. This study aimed to explore the antibacterial a...
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Article
Open AccessHeat stress-induced NO enhanced perylenequinone biosynthesis of Shiraia sp. via calcium signaling pathway
Perylenequinones (PQs) are natural photosensitizing compounds used as photodynamic therapy, and heat stress (HS) is the main limiting factor of mycelial growth and secondary metabolism of fungi. This study aim...
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Open AccessTranscriptome analysis of Kluyveromyces marxianus under succinic acid stress and development of robust strains
Kluyveromyces marxianus has become an attractive non-conventional yeast cell factory due to its advantageous properties such as high thermal tolerance and rapid growth. Succinic acid (SA) is an important platform...
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Open AccessNovel anti-inflammatory diketopiperazine alkaloids from the marine-derived fungus Penicillium brasilianum
Diketopiperazine alkaloids have proven the most abundant heterocyclic alkaloids up to now, which usually process diverse scaffolds and rich biological activities. In our search for bioactive diketopiperazine a...
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A previously unidentified sugar transporter for engineering of high-yield Streptomyces
Sugar transporters have significant contributions to regulate metabolic flux towards products and they are general potential targets for engineering of high-yield microbial cell factories. Streptomyces, well-know...
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Open AccessDevelopment and evaluation of a test strip for the rapid detection of antibody against equine infectious anemia virus
Equine infectious anemia (EIA) is a contagious disease of horses caused by the equine infectious anemia virus (EIAV). The clinical signs at the acute phase include intermittent high fever, thrombocytopenia, he...
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Effects of fecal microbial transplantation on police performance and transportation stress in Kunming police dogs
Fecal microbiota transplantation (FMT) has been shown to improve gut dysbiosis in dogs; however, it has not completely been understood in police dogs. This study aimed to investigate the effects of FMT on perf...
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Detecting and quantifying Veillonella by real-time quantitative PCR and droplet digital PCR
Veillonella spp. are Gram-negative opportunistic pathogens present in the respiratory, digestive, and reproductive tracts of mammals. An abnormal increase in Veillonella relative abundance in the body is closely...
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Fermentation of waste water from agar processing with Bacillus subtilis by metabolomic analysis
Fungal infection has become a major threat to crop loss and affects food safety. The waste water from agar processing industries extraction has a number of active substances, which could be further transformed...
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Article
Response of Paenibacillus polymyxa SC2 to the stress of polymyxin B and a key ABC transporter YwjA involved
Polymyxins are cationic peptide antibiotics and regarded as the “final line of defense” against multidrug-resistant bacterial infections. Meanwhile, some polymyxin-resistant strains and the corresponding resis...
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Association between host nitrogen absorption and root-associated microbial community in field-grown wheat
Plant roots and rhizosphere soils assemble diverse microbial communities, and these root-associated microbiomes profoundly influence host development. Modern wheat has given rise to numerous cultivars for its ...
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Article
Phytosterol conversion into C9 non-hydroxylated derivatives through gene regulation in Mycobacterium fortuitum
Androst-4-ene-3,17-dione (AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) are important drug intermediates that can be biosynthesized from phytosterols. However, the C9 hydroxylation of steroids via 3-...
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Tetanus toxin and botulinum neurotoxin–derived fusion molecules are effective bivalent vaccines
Tetanus toxin (TeNT) and botulinum neurotoxins (BoNTs) are neuroprotein toxins, with the latter being the most toxic known protein. They are structurally similar and contain three functional domains: an N-term...
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Biotechnological production and potential applications of hypocrellins
Hypocrellins (HYPs), a kind of natural perylenequinones (PQs) with an oxidized pentacyclic core, are important natural compounds initially extracted from the stromata of Hypocrella bambusae and Shiraia bambusicol...
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Characterization of a novel monooxygenase originating from a deep-sea sediment metagenomic library
Oxygenases are important biocatalysts to produce many industrially important biomolecules. Here, a novel oxygenase, named MoxA, was identified through screening of a deep-sea sediment metagenomic library. Sequ...
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Open AccessWhole genome sequencing and analysis of selenite-reducing bacteria Bacillus paralicheniformis SR14 in response to different sugar supplements
The biosynthetic process of selenium nanoparticles (SeNPs) by specific bacterial strain, whose growth directly affects the synthesis efficiency, has attracted great attentions. We previously reported that Bacillu...
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Comparison of microbial communities and volatile profiles of wines made from mulberry and grape
In this study, three kinds of wines separately made from mulberry (MW), grape (GW), or mulberry/grape (MGW) were developed and their enological parameters, sensory scores, volatile components, and microbiota w...
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Natural products from marine fungi as a source against agricultural pathogenic fungi
There are many kinds of agricultural pathogenic fungi, which may belong to pathogenic fungi in different species, such as Fusarium, Alternaria, Colletotrichum, Phytophthora, and other agricultural pathogens. Pat...
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Novel β1,4 N-acetylglucosaminyltransferase in de novo enzymatic synthesis of hyaluronic acid oligosaccharides
The efficiency of de novo synthesis of hyaluronic acid (HA) using Pasteurella multocida hyaluronate synthase (PmHAS) is limited by its low catalytic activity during the initial reaction steps when monosaccharides...
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Regulation of Cat8 in energy metabolic balance and glucose tolerance in Saccharomyces cerevisiae
Cat8 is a C6 zinc cluster transcription activator in yeast. It is generally recognized that the transcription of CAT8 is inhibited and that Cat8 is inactive in the presence of high concentrations of glucose. Howe...
