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  1. No Access

    Article

    Stiffened Extracellular Matrix and Signaling from Stromal Fibroblasts via Osteoprotegerin Regulate Tumor Cell Invasion in a 3-D Tumor in Situ Model

    Several changes have been described in the stroma surrounding a tumor, including changes in cellular composition, altered extracellular matrix composition and organization, and increases in stiffness. Tumor ce...

    Joshua S. McLane, Lee A. Ligon in Cancer Microenvironment (2016)

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    Protocol

    Electrospun Nanofiber Scaffolds for Investigating Cell–Matrix Adhesion

    It has become increasingly clear that the cellular microenvironment, in particular the extracellular matrix, plays an important role in regulating cell function. However, the extracellular matrix is extraordin...

    Joshua S. McLane, Nicholas J. Schaub, Ryan J. Gilbert… in Adhesion Protein Protocols (2013)

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    Article

    Dynein binds to β-catenin and may tether microtubules at adherens junctions

    Interactions between microtubule and actin networks are thought to be crucial for mechanical and signalling events at the cell cortex. Cytoplasmic dynein has been proposed to mediate many of these interactions1,2

    Lee A. Ligon, Sher Karki, Mariko Tokito, Erika L. F. Holzbaur in Nature Cell Biology (2001)