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Article
Open AccessTumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains elusive. Here, we find T-cell exhaustion linked to overall surviv...
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Article
The effects of platelet accumulation in fatty liver disease
A new study provides evidence that platelets exert potent inflammatory effects and play a central part in the progression from simple steatosis to nonalcoholic steatohepatitis. The results from this and other ...
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Article
Practice patterns of VTE chemoprophylaxis after discharge following hepatic and pancreatic resections for cancer: A survey of hepatopancreatobiliary surgeons
Patients with hepatopancreatobiliary (HPB) malignancies undergoing resection are prone to venous thromboembolism (VTE), and current guidelines recommend up to 28 days of chemoprophylaxis after major surgery. W...
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Article
Open AccessMetabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy
Esophageal cancers accounted for nearly 16,000 deaths in 2016. The number of patients with esophageal cancers increases every year. Neoadjuvant chemoradiotherapy (nCRT) prior to esophagectomy is a standard tre...
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Article
Open AccessUtility of PD-L1 immunohistochemistry assays for predicting PD-1/PD-L1 inhibitor response
We have seen a notable increase in the application of PD-1/PD-L1 inhibitors for the treatment of several solid and hematogenous malignancies including metastatic melanoma, non-small-cell lung cancer and lympho...
