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  1. No Access

    Article

    Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics

    Reactive oxygen species (ROS) and antioxidants are essential to maintain a redox balance within tissues and cells. Intracellular ROS regulate key cellular functions such as proliferation, differentiation and a...

    Wanakee J. Carr, Rebecca E. Oberley-Deegan, Yu** Zhang… in Histochemistry and Cell Biology (2011)

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    Article

    Effect of expression of manganese superoxide dismutase in baculovirus-infected insect cells

    It has previously been demonstrated that baculovirus infection of the Spodoptera frugiperda Sf-9 (Sf-9) and Trichoplusia ni BTI-Tn-5B1-4 (Tn-5B1-4) insect cell lines leads to oxidative stress as measured by prote...

    Ying Wang, Larry W. Oberley, Dale Howe… in Applied Biochemistry and Biotechnology (2004)

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    Chapter

    Eicosapentaenoic Acid Alters Manganese Superoxide Dismutase Immunoreactive Protein Levels in Normal But not Maligant Central Nervous System Derived Cells

    The dose of radiation that safely can be administered to patients with malignant gliomas is limited by the potential for severe CNS morbidity. Manipulations that might increase the radiation sensitivity of gli...

    Geoffrey D. Girnun, Larry W. Oberley… in Eicosanoids and Other Bioactive Lipids in … (1999)

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    Article

    Overexpression of Glia Maturation Factor in C6 Cells Promotes Differentiation and Activates Superoxide Dismutase

    In order to evaluate the intracellular function of glia maturation factor (GMF), we overexpressed GMF in C6 rat glioma cells using two methods: stable transfection using the pcDNA3 plasmid, and transient trans...

    Ramon Lim, Asgar Zaheer, Jeff A. Kraakevik, Christine J. Darby… in Neurochemical Research (1998)

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    Article

    Role of antioxidant enzymes in cell immortalization and transformation

    The role of antioxidant enzymes, particularly superoxide dismutase (SOD), in immortalization and malignant transformation is discussed. SOD (generally MnSOD) has been found to be lowered in a wide variety of t...

    Larry W. Oberley, Terry D. Oberley in Molecular and Cellular Biochemistry (1988)

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    Article

    Pharmacologic activities of copper compounds in chronic diseases

    Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypo...

    John R. J. Sorenson, Larry W. Oberley… in Biological Trace Element Research (1983)

  7. No Access

    Chapter

    Antitumor SOD Compounds

    Many studies have been recently performed on the activity of the enzyme superoxide dismutase (SOD) in tumor cells. This enzyme catalyzes the reaction ...

    Larry W. Oberley, Susan W. C. Leuthauser… in Inflammatory Diseases and Copper (1982)