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  1. No Access

    Article

    Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor

    Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1α subunit and an HI...

    Min Wang, Jeanie S Kirk, Sujatha Venkataraman, Frederick E Domann… in Oncogene (2005)

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    Article

    Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells

    This study investigates the role of the antioxidant enzyme manganese superoxide dismutase (MnSOD) in androgen-independent human prostate cancer (PC-3) cells' growth rate in vitro and in vivo. MnSOD levels were fo...

    Sujatha Venkataraman, **aohong Jiang, Christine Weydert, Yu** Zhang… in Oncogene (2005)

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    Article

    Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1

    Increased expression of mac25/insulin-like growth factor binding-protein related protein-1 (IGFBP-rP1) in human breast and prostate epithelial cell lines results in the suppression of tumor growth. CDNA expres...

    Stephen R Plymate, Kathy H Haugk, Cynthia C Sprenger, Peter S Nelson… in Oncogene (2003)

  4. No Access

    Article

    Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase

    Manganese superoxide dismutase (MnSOD) has been previously shown to suppress the malignant phenotype of human melanoma and breast cancer cells. To test the possible role of MnSOD in glioma malignancy, MnSOD wa...

    Weixiong Zhong, Larry W Oberley, Terry D Oberley, Daret K St Clair in Oncogene (1997)