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  1. Article

    Open Access

    Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

    Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/th...

    **gyi Li, **ngfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang… in Cell Death & Disease (2024)

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  2. Article

    Open Access

    Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis

    Necroptosis is a form of regulated cell death that has been implicated in multiple diseases. TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL. In this study, by...

    Fangmin Huang, Jiankun Liang, Yingying Lin, Yushi Chen, Fen Hu… in Communications Biology (2023)

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  3. Article

    Open Access

    The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

    Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is de...

    Lanqin Wu, Yingying Lin, **an Feng, Yuanlin Qi, **nrui Wang… in Cancer Cell International (2019)

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