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Open AccessAccelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer
The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was intro...
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Article
Open AccessRapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America
Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b underwent an explosive geographic expansion in 2021 among wild birds and domestic poultry across Asia, Europe, and Africa. By the end of 2021...
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Editorial
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
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Chapter
27. Japan
Japan is sometimes categorised as a constitutional monarchy. However, this categorisation can be controversial and Japan has adopted the philosophy that the emperor is the symbol of the state and of the unity ...
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Article
Open AccessToward the identification of genetic determinants of breast cancer immune responsiveness
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Article
A filament of dark matter between two clusters of galaxies
A dark-matter filament connecting the galaxy clusters Abell 222 and Abell 223 has been detected from its weak gravitational lensing signal.
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Article
Open AccessIntrinsic molecular signature of breast cancer in a population-based cohort of 412 patients
Molecular markers and the rich biological information they contain have great potential for cancer diagnosis, prognostication and therapy prediction. So far, however, they have not superseded routine histopath...
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Article
Open AccessGene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
Adjuvant breast cancer therapy significantly improves survival, but overtreatment and undertreatment are major problems. Breast cancer expression profiling has so far mainly been used to identify women with a ...
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THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma
Using oligonucleotide microarray analysis, THY1, map** close to a previously defined 11q22–23 nasopharyngeal carcinoma (NPC) critical region was identified as showing consistent downregulated expression in the ...
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Chapter
The White Dwarf Population in the 2QZ and Sloan Surveys
We present an analysis of the Anglo-Australian Telescope 2dF QSO Redshift Survey (2QZ) of high-Galactic latitude white dwarf stars. Approximately 2400 white dwarfs have been identified with distances above the...
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Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration
lnterleukin-2 (IL-2) has direct pluripotent effects on cells with immune and inflammatory function. Which of these effects has a critical role in mediating tumor regression remains enigmatic. In this study, we...
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Silencing of Wnt signaling and activation of multiple metabolic pathways in response to cell proliferation stimulated by thyroid hormone
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Agn Host Galaxies: HST at Z ~ 0.1 and Gemini Adaptive Optics at Z ~ 2
A study of 76 host galaxies of Active Galactic Nuclei (AGN) in the local universe (z ~ 0. 1) carried out with Hubble Space Telescope shows that these hosts are remarkably similar to typical field galaxies. They h...
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Parse Fitting and Prose Fixing
Processing syntactically ill-formed language is an important mission of a text-critiquing system. This chapter discusses how ill-formed input is treated by Epistle, the forerunner of Critique. Misspellings are...
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Article
Faint active galaxy puzzle
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Radio Sources and Cooling Flows
What effect do radio sources have on their surroundings, and in particular, what effect do radio sources in clusters of galaxies have on the cooling of the intracluster gas? It is shown here how a lower limit ...
