9 Result(s)
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Sofya K. Garushyants
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Article
Open AccessMicrobial diversity and ecological complexity emerging from environmental variation and horizontal gene transfer in a simple mathematical model
Microbiomes are generally characterized by high diversity of coexisting microbial species and strains, and microbiome composition typically remains stable across a broad range of conditions. However, under fix...
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Open AccessAccelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer
The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was intro...
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Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We present programmable addition via site-spe...
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Open AccessSARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19
Evolution of SARS-CoV-2 in immunocompromised hosts may result in novel variants with changed properties. While escape from humoral immunity certainly contributes to intra-host evolution, escape from cellular i...
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Open AccessTemplate switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoring
The appearance of multiple new SARS-CoV-2 variants during the COVID-19 pandemic is a matter of grave concern. Some of these variants, such as B.1.617.2, B.1.1.7, and B.1.351, manifest higher infectivity and vi...
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Open AccessGenomic epidemiology of the early stages of the SARS-CoV-2 outbreak in Russia
The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use of phylogenetics to understand and control its spread. Here, we analyze the emergence of SARS-CoV-2 in Russia in March...
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Open AccessMicrobiomes of gall-inducing copepod crustaceans from the corals Stylophora pistillata (Scleractinia) and Gorgonia ventalina (Alcyonacea)
Corals harbor complex and diverse microbial communities that strongly impact host fitness and resistance to diseases, but these microbes themselves can be influenced by stresses, like those caused by the prese...
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Open AccessGenome analysis of E. coli isolated from Crohn’s disease patients
Escherichia coli (E. coli) has been increasingly implicated in the pathogenesis of Crohn’s disease (CD). The phylogeny of E. coli isolated from Crohn’s disease patients (CDEC) was cont...
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Open AccessHorizontal gene transfer and genome evolution in Methanosarcina
Genomes of Methanosarcina spp. are among the largest archaeal genomes. One suggested reason for that is massive horizontal gene transfer (HGT) from bacteria. Genes of bacterial origin may be involved in the centr...
