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Open AccessOn the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships
Functional human-on-a-chip systems hold great promise to enable quantitative translation to in vivo outcomes. Here, we explored this concept using a pumpless heart only and heart:liver system to evaluate the temp...
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Protocol
Contractile Force Readout of hESC-Cardiomyocytes
Promising pharmaceuticals frequently fail clinical trials due to cardiotoxicity or a decline in heart function not indicated from preclinical animal models and in vitro tests. The development of low-cost, high...
