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Article
Open AccessRole of PAI-1 in hepatic steatosis and dyslipidemia
Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic contributor to several elements of the syndrome, in...
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Protocol
Contractile Force Readout of hESC-Cardiomyocytes
Promising pharmaceuticals frequently fail clinical trials due to cardiotoxicity or a decline in heart function not indicated from preclinical animal models and in vitro tests. The development of low-cost, high...
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Article
Open AccessMulti-Organ toxicity demonstration in a functional human in vitro system composed of four organs
We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system under continuous flow conditions in a serum-free defined medium utilizing a pumpless platform for 14 days. Computer si...
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Article
CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract
To evaluate the effect of cocoa flavonoids in breast cancer cells at the molecular level, a functional genomic analysis was performed using a polyphenolic cocoa extract (PCE) in MCF-7 and SKBR3 cell lines.
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Article
Open AccessNetworking of differentially expressed genes in human cancer cells resistant to methotrexate
The need for an integrated view of data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize how external perturbations propagate through the exp...
