6 Result(s)
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L. Paczek
Internal Medicine
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Article
Open AccessReversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report
Cardiorenal syndrome (CRS) is a group of pathophysiological disorders affecting heart and kidneys.
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Article
Mechanism of antinephritic effect of proteinase inhibitors in experimental anti-GBM glomerulopathy
We have previously documented amelioration of rat autologous anti-GBM nephritis with the antiproteolytic drugs ε-aminocaproic acid (EACA) and aprotinin, given from the day of induction or later in the course o...
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Article
Dose-dependent stimulation/inhibition effects of cyclosporin A on lysosomal cathepsin activities in cultured proximal tubule cells
The effects of cyclosporin A on the activities of lysosomal cysteine proteinases (cathepsin B, H, L+B) in LLC-Pk1 cells were investigated to elucidate their potential role in cyclosporin A-induced nephrotoxici...
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Article
Lovastatin ameliorates depressed intraglomerular proteolytic activities in experimental nephrotic syndrome
Lipid abnormalities have been implicated in the pathogenesis of glomerulosclerosis in experimental models of kidney disease. In previous studies it has been shown that Adriamycin-induced nephropathy is associa...
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Article
Obese zucker rat: Potential role of intraglomerular proteolytic enzymes in the development of glomerulosclerosis
The obese Zucker rat is a classic model of non-immune-mediated spontaneous focal glomerulosclerosis. An early morphological hallmark of glomerular damage in the obese Zucker rat is a mesangial expansion, which...
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Article
Intraglomerular fibronectin accumulation and degradation in obese Zucker rats
The obese Zucker rat is a classic model of non-immune mediated spontaneous focal glomerulosclerosis. An important initiating hallmark of glomerulosclerosis in this model is mesangial matrix expansion. Fibronec...
