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Open AccessReversal of stage 5 chronic kidney disease by aortic valve replacement in kidney transplant recipient: a case report
Cardiorenal syndrome (CRS) is a group of pathophysiological disorders affecting heart and kidneys.
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Article
Open AccessUrine proteomes of healthy aging humans reveal extracellular matrix (ECM) alterations and immune system dysfunction
Aging is a complex physiological process that poses considerable conundrums to rapidly aging societies. For example, the risk of dying from cardiovascular diseases and/or cancer steadily declines for people af...
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Age-related decrease in the activity of collagenase in the femoral head in patients with hip osteoarthritis
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Article
Randomised open clinical trial of conversion from mycophenolate mofetil to azathioprine in cadaveric renal transplantation
Mycophenolate mofetil (MMF) is a powerful immunosuppressive drug with established efficacy and safety. The search for a less expensive immunosuppressive protocol has led to an open randomised clinical trial o...
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Article
Mechanism of antinephritic effect of proteinase inhibitors in experimental anti-GBM glomerulopathy
We have previously documented amelioration of rat autologous anti-GBM nephritis with the antiproteolytic drugs ε-aminocaproic acid (EACA) and aprotinin, given from the day of induction or later in the course o...
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Article
Dose-dependent stimulation/inhibition effects of cyclosporin A on lysosomal cathepsin activities in cultured proximal tubule cells
The effects of cyclosporin A on the activities of lysosomal cysteine proteinases (cathepsin B, H, L+B) in LLC-Pk1 cells were investigated to elucidate their potential role in cyclosporin A-induced nephrotoxici...
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Article
Lovastatin ameliorates depressed intraglomerular proteolytic activities in experimental nephrotic syndrome
Lipid abnormalities have been implicated in the pathogenesis of glomerulosclerosis in experimental models of kidney disease. In previous studies it has been shown that Adriamycin-induced nephropathy is associa...
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Article
Obese zucker rat: Potential role of intraglomerular proteolytic enzymes in the development of glomerulosclerosis
The obese Zucker rat is a classic model of non-immune-mediated spontaneous focal glomerulosclerosis. An early morphological hallmark of glomerular damage in the obese Zucker rat is a mesangial expansion, which...
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Article
Intraglomerular fibronectin accumulation and degradation in obese Zucker rats
The obese Zucker rat is a classic model of non-immune mediated spontaneous focal glomerulosclerosis. An important initiating hallmark of glomerulosclerosis in this model is mesangial matrix expansion. Fibronec...
