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Article
Sarcopenia: Biomarkers and imaging (International Conference on Sarcopenia research)
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Article
Exposure estimates in studies on workplace exposures to trichloroethylene in relation to renal cell cancer formation – a reply
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Article
Renal cell cancer correlated with occupational exposure to trichloroethylene: reply to letter to the editors
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Article
Renal cell cancer correlated with occupational exposure to trichloroethene
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Article
Changes in the classification of carcinogenic chemicals in the work area
Carcinogenic chemicals in the work area were previously classified into three categories in section III of the German List of MAK and BAT values (the list of values on maximum workplace concentrations and bio‐lo...
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Article
Renal cell cancer correlated with occupational exposure to trichloroethene
A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is associated with an increased incidence of renal cell cancer. The present h...
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Chapter and Conference Paper
Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesis
Extragenomic changes play a crucial role in the regulation of gene expression and consequently in cell proliferation and differentiation. Hence, changes in cellular components other than the genome may influen...
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Article
Occupational exposure to perchloroethylene
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Article
Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine
The nephrotoxic effects of the two isomers S-(1,2-dichlorovinyl)-l-cysteine (1,2-DCVC) and S-(2,2-dichlorovinyl)-l-cysteine (2,2-DCVC) were investigated comparatively in the isolated perfused rat kidney with two ...
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Article
Increased incidence of renal cell tumours in a cohort of cardboard workers exposed to trichloroethylene
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Article
Dose-dependent stimulation/inhibition effects of cyclosporin A on lysosomal cathepsin activities in cultured proximal tubule cells
The effects of cyclosporin A on the activities of lysosomal cysteine proteinases (cathepsin B, H, L+B) in LLC-Pk1 cells were investigated to elucidate their potential role in cyclosporin A-induced nephrotoxici...
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Article
Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene
A retrospective cohort study was carried out in a cardboard factory in Germany to investigate the association between exposure to trichloroethene (TRI) and renal cell cancer. The study group consisted of 169 m...
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Article
Induction of morphologically and biochemically altered LLC-PK1 clones after long-term exposure to the nephrotoxin and nephrocarcinogen dichlorovinylcysteine
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Article
The nephrotoxin dichlorovinylcysteine induces expression of the protooncogenesC-fos andC-myc in LLC-PK1 cells—A comparative investigation with growth factors and 12-O-tetradecanoylphorbolacetate
Previous studies in kldney cells showed that S-(l,2-dichloroviny1)-L-cysteitle (DCVC) induces both direct DNA damage and DNA double-strand breaks by activation of Ca2+-dependent endonucleases. The objective of th...
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Chapter
Characterization of an Unscheduled DNA Synthesis Assay with a Cultured Line of Porcine Kidney Cells (LLC-PK1)
Proximal tubular cells are a primary site of tumour formation in the kidney probably due both to high exposure to absorbed chemicals and their multiple transport and bioactivation capacities (1). It is therefo...