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Article
Ephaptic Feedback in Identified Synapses in Mollusk Neurons
The possible existence of intrasynaptic ephaptic feedback in the invertebrate CNS was studied. Intracellular recordings were made of excitatory postsynaptic potentials and currents arising on activation of the...
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Article
Stimulation of the Lateral Hypothalamus Provokes the Initiation of Robust Long-Term Potentiation of the Thalamo-Cortical Input to the Barrel Field of the Adult, Freely Moving Rat
Long-term potentiation in the thalamo-cortical input to the somatosensory cortex barrel field has been reported to be inducible in vitro only during a narrow critical period of the first postnatal week. Here w...
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Article
The Potentiation of Hippocampal Responses at Positive Membrane Potential Reveals the Presynaptic Nature of the Low Efficacy of “Silent” Synapses
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Article
Correlation between Paired Responses Confirms the Existence of a Positive Ephaptic Feedback in Central Synapses
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Article
Long-Term Potentiation of the AMPA and NMDA Components of Minimal Postsynaptic Currents in Rat Hippocampal Field Ca1
The aim of the present work was to study the potentiation of the AMPA and NMDA components of minimal excitatory postsynaptic currents (EPSC) evoked by activation of restricted numbers of synapses. EPSC of neur...
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Article
Intrasynaptic ephaptic feedback in central synapses
Electrophysiological laboratory studies on rat visual cortex and hippocampus slices are reviewed. The aim was to confirm the existence of positive feedback in central synapses operating by an electrical (ephap...
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Article
Intracellular studies of the interaction between paired-pulse facilitation and the delayed phase of long-term potentiation in the hippocampus
The mechanisms of the early (up to 1 h) and late (up to 3 h) phases of long-term potentiation were studied by analyzing the interaction between long-term potentiation and presynaptic paired-pulse facilitation....
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Article
Determination of Pre- and post-tetanic quantum values in excitatory synapses of CA1 area of hippocampal slices: Application of the deconvolution method
The deconvolution method, i.e., reconstruction of noise-free discrete amplitude distributions of excitatory postsynaptic potentials (EPSPs), has been tested in computer experiments. A “generalized quantal mode...
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Article
Estimate of the quantum value variability in excitatory synapses of CA1 area in hippocampal slices and its effects on the quantum value estimate
Excitatory postsynaptic potentials (EPSPs) evoked by near-threshold stimulation of the radial layer were recorded from the CA1 area of guinea pig hippocampal slices. An optimization method based on the deconvo...
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Article
Quantal parameters of “minimal” excitatory postsynaptic potentials in guinea pig hippocampal slices: binomial approach
Binomial distributions of amplitudes of excitatory postsynaptic potentials (EPSPs) mixed with Gaussian noise were simulated. The objective of Monte Carlo simulations was, firstly, to study influences of sampli...
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Article
Quantal analysis of long-term potentiation of “minimal” excitatory postsynaptic potentials in guinea pig hippocampal slices: binomial approach
“Minimal” excitatory postsynaptic potentials (EPSPs) were recorded from 13 neurones in area CA1 of guinea pig hippocampal slices after double-pulse stimulation of stratum radiatum (str. rad.) and stratum orien...
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Article
Statistical analysis of long-term potentiation of large excitatory postsynaptic potentials recorded in guinea pig hippocampal slices: binomial model
Excitatory postsynaptic potentials (EPSPs) were recorded in guinea pig hippocampal slices (area CA1) from 15 neurones after stimulation of stratum radiatum (str. rad.) and stratum oriens. EPSP amplitudes incre...
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Article
Analysis of fluctuations of “minimal” excitatory postsynaptic potentials during long-term potentiation in guinea pig hippocampal slices
In previous studies, quantal analysis assuming a simple binomial model has shown that long-term potentiation (LTP) is accompanied by an increase in both mean quantal content (m) and quantal size (v), whereby t...
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Article
Suppression of "fast" IPSP, superposed on "slow", as a possible cause of priming in murine hippocampus
Intra- and extracellular response in area CA1 to stimulation of two independent afferent inputs, one a priming or conditioned and the other a test or primed input (C1 and C2, respectively) were recorded in sur...
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Article
Quantal analysis of long-term posttetanic changes in minimal postsynaptic potentials of hippocampal slices in vitro
Minimal excitatory postsynaptic potentials (EPSP) were investigated in 13 neurons under single or double-pulse near-threshold microstimulation of the radial layer (Schaffer's collaterals) and stratum oriens in...
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Article
Quantal analysis of long-term potentiation of combined neuronal postsynaptic potentials on hippocampal slices in vitro
Excitatory postsynaptic potentials (EPSP) were recorded from 14 neurons in guinea pig hippocampal slices (area CAl) after stimulating the stratum radiatum (Schaffer collaterals) and stratum oriens. An increase...
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Article
Statistical methods of quantal analysis in computerized compared with physiological experiments
Amplitude distributions of postsynaptic potentials subject to binomial distribution were simulated in computer-based experiments. Effects of sample size (N) and standard deviation of noise (Sn) on accuracy of det...
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Article
Suppression of associative long-term potentiation in the hippocampus after tetanization of reinforcing afferents
Field potentials (FP) induced in area C1 by gentle orthodromic stimulation were recorded in murine hippocampal slices and associative long-term potentiation (ALTP) produced by C2 tetanization associated with i...
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Chapter and Conference Paper
Quantal Analysis of Long-Term Potentiation
Quantal analysis was performed on evoked EPSPs recorded from hippocampal neurones in in vivo (rabbit) and in in vitro (guinea pig) preparations. In one series of experiments double pulse stimulation was used. In ...
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Article
Synaptic plasticity at archicortical and neocortical levels
Research carried out by the author and his collaborators, devoted to analysis of the properties and neurophysiological mechanisms of long-term (for several hours) potentiation, is surveyed. Long-term potentiat...
