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  1. No Access

    Article

    Population differences in S-warfarin pharmacokinetics among African Americans, Asians and whites: their influence on pharmacogenetic dosing algorithms

    Using population pharmacokinetic analysis (PPK), we attempted to identify predictors of S-warfarin clearance (CL(S)) and to clarify population differences in S-warfarin pharmacokinetics among a cohort of 378 Afri...

    K Kubo, M Ohara, M Tachikawa, L H Cavallari, M T M Lee… in The Pharmacogenomics Journal (2017)

  2. No Access

    Article

    Ethnicity-specific pharmacogenetics: the case of warfarin in African Americans

    Using a derivation cohort (N=349), we developed the first warfarin dosing algorithm that includes recently discovered polymorphisms in VKORC1 and CYP2C9 associated with warfarin dose requirement in African Americ...

    W Hernandez, E R Gamazon, K Aquino-Michaels, S Patel… in The Pharmacogenomics Journal (2014)

  3. No Access

    Article

    β-Adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography

    Our objective was to determine if β1-adrenergic receptor (β1-AR) and β2-AR gene polymorphisms influence heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) response to dobutamine dur...

    C L Aquilante, H N Yarandi, L H Cavallari, T E Andrisin… in The Pharmacogenomics Journal (2008)

  4. No Access

    Article

    Association between β-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study

    The β-adrenergic receptor (βAR) genes are candidate genes for obesity because of their roles in energy homeostasis and promotion of lipolysis in human adipose tissue. Objective is to determine the association bet...

    S G Terra, S P McGorray, R Wu, D M McNamara… in International Journal of Obesity (2005)