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Article
Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B
Entecavir (ETV) is a potent nucleoside analogue against hepatitis B virus (HBV), and emergence of drug resistance is rare in nucleoside-naive patients because development of ETV resistance (ETVr) requires at l...
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Article
Studies on oxidative stress in liver diseases: important future trends in liver research
Oxidative stress has recently been shown to play an important role in various liver diseases. Therefore, further studies on oxidative stress in liver diseases are urgently required. In this review, oxidative s...
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Chapter and Conference Paper
Hepatic Iron Staining in Chronic Hepatitis C Patients with Low HCV RNA Levels as a Predictive Marker for Interferon Therapy
Objectives: Interferon (IFN) therapy is ineffective in about 20%–30% of chronic hepatitis C (CH-C) patients with low hepatitis C virus (HCV) RNA levels. Besides the serum HCV RNA level or HCV genotype, hepatic...
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Article
Much remains to be solved in lamivudine treatment for HBV-associated liver diseases
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Chapter and Conference Paper
Present Status and Future of Gene Therapy for Hepatic Fibrosis
The definition of the molecular and genetic basis of human liver diseases has led to a better understanding of their pathogenesis and has in addition offered new perspectives for their diagnosis, therapy, and ...
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Article
High prevalence of anticardiolipin antibodies in hepatitis C virus infection: lack of effects on thrombocytopenia and thrombotic complications
Hepatitis C virus (HCV) causes various extrahepatic immunologic abnormalities. Recently, an association between HCV infection and antiphospholipid syndrome, including thrombocytopenia, has been reported. Howe...
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Article
Erythropoietic protoporphyria with fatal liver failure
A 33-year-old woman with a history of photosensitivity, persistent abdominal pain, and liver dysfunction was admitted to our department because of abdominal pain and progression of liver dysfunction. On admis...
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Article
β1-Integrin mediates cell adhesion, haptotaxis, and chemokinesis of hepatoma cells
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Article
Antiphospholipid syndrome modifies the clinical features of systemic lupus erythematosus
A 17-year-old woman with arterial and venous thrombosis of the leg diagnosed as antiphospholipid syndrome (APS) associated with systemic lupus erythematosus (SLE) is reported. Her serum C-reactive protein (CRP...
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Chapter and Conference Paper
Changes in Adhesion Molecules of Sinusoidal Endothelial Cells in Liver Injury
Interactions between leukocytes and sinusoidal endothelial cells have been known to be involved in the pathogenesis of acute liver injury. In these cell-to-cell interactions, various adhesion molecules play a ...
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Chapter and Conference Paper
Congenital Lipidosis
We studied livers from patients with cholesterol ester storage disease and Gaucher’s disease by light and electron microscopy, and present their morphological features. A 57-year-old male with a complaint of r...
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Chapter and Conference Paper
High Prevalence of HCV Infection in Patients with Oral Cancer and Oral Precancerous Lesion
Hepatitis C virus (HCV) leads to serious consequences such as liver cirrhosis and hepatocellular carcinoma. Other than liver disease, HCV infection is associated with various extrahepatic manifestations and im...
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Chapter and Conference Paper
Hepatic Innervation and Hepatic Sinusoidal Cells
The innervation of the human liver is distributed throughout the hepatic lobules from the portal spaces to the centralobular spaces. Nerve endings in the intralobular spaces are localized mainly in the Disse s...
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Chapter and Conference Paper
The Role of Neutrophils in Liver Cell Injury in Alcoholic Hepatitis
We describe the role of neutrophils in the pathogenesis of alcoholic hepatitis (AH). Endotoxemia, leukocytosis in the peripheral blood, and infiltration of the liver by neutrophils are common features in patie...
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Chapter and Conference Paper
The Intestine, Spleen, and Liver
Blood from the intestine and the spleen flows directly into the liver. Numerous antigenic substances, including endotoxin, are absorbed from the intestine and go to the liver. The spleen, which contains at lea...
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Chapter and Conference Paper
Natural Killer Cells in the Liver and Their Activators
An impaired host defense mechanism is well known in patients with liver cirrhosis. To clarify the sight of natural resistance in the liver, we investigated hepatic natural killer (NK) activity, and a proportio...
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Chapter and Conference Paper
Cholestasis and Hepatic Sinusoidal Cells
The aim of this study was to evaluate the morphological and functional changes in Kupffer cells and sinusoidal endothelial cells in cholestasis. Under an electron microscope, Kupffer cells in cholestasis were ...
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Chapter and Conference Paper
Angiogenesis of Cultured Rat Sinusoidal Endothelial Cells
We have previously shown that rat sinusoidal endothelial cells cultured on Matrigel presented a great number of tube-like structures, forming a network, on the surface of the gel. In the present study, using t...
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Chapter and Conference Paper
Contraction and Relaxation of Ito Cells
Ito cells (hepatic stellate cells) are localized around liver sinusoidal endothelial cells. The cytoplasm of these cells contains contractile proteins such as actin and myosin, suggesting that microcirculation...
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Chapter and Conference Paper
Diagnosis and Treatment of Hepatic Fibrosis and Hepatic Sinusoidal Cells
Hepatic fibrosis is a common response to chronic liver injury from many causes, including alcohol, chronic viral infections, metabolic liver disorders, and autoimmune hepatitis. Hepatic fibrosis results from a...
