Summary
Blood from the intestine and the spleen flows directly into the liver. Numerous antigenic substances, including endotoxin, are absorbed from the intestine and go to the liver. The spleen, which contains at least one-third of the lymphatic tissue in the body, responds to antigenic substances, including endotoxin, and produces numerous cytokines, antibodies, and antigen-specific T cells which first flow into the liver. Thus, the intestine and spleen strongly affect the liver, and endotoxin seems to play an important role in modulating the effect of both organs. This chapter investigates the importance of these organs in the pathogenesis of various liver diseases, including alcoholic hepatitis, obstructive jaundice, and primary biliary cirrhosis.
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© 1999 Springer-Verlag Tokyo
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Tanikawa, K. (1999). The Intestine, Spleen, and Liver. In: Tanikawa, K., Ueno, T. (eds) Liver Diseases and Hepatic Sinusoidal Cells. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67935-6_1
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DOI: https://doi.org/10.1007/978-4-431-67935-6_1
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68012-3
Online ISBN: 978-4-431-67935-6
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