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  1. No Access

    Article

    Prognostic value of dynamic changes of pre- and post-operative tumor markers in colorectal cancer

    Colorectal cancer (CRC) prognosis assessment is vital for personalized treatment plans. This study investigates the prognostic value of dynamic changes of tumor markers CEA, CA19-9, CA125, and AFP before and a...

    Guangming Ren, Gaozan Zheng, Kunli Du… in Clinical and Translational Oncology (2024)

  2. Article

    Open Access

    Prognostic value of normal levels of preoperative tumor markers in colorectal cancer

    Carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125), and alpha-fetoprotein (AFP) are widely used tumor markers for colorectal cancer (CRC), but their clinical s...

    Guangming Ren, Ruikai Li, Gaozan Zheng, Kunli Du, Hanjun Dan… in Scientific Reports (2023)

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  3. Article

    Open Access

    Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment

    The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This study used a multi-omics approach, integrating single-cell...

    Zhenyu **e, Liaoran Niu, Gaozan Zheng, Kunli Du, Songchen Dai… in Cell & Bioscience (2023)

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  4. No Access

    Article

    High Expression of PhospholipaseD2 Induced by Hypoxia Promotes Proliferation of Colon Cancer Cells through Activating NF- κ Bp65 Signaling Pathway

    Hypoxia is a typical feature of colon cancer occurrence and progression. We have reported that high expression and activity of PhospholipaseD2 (PLD2) induced by hypoxia in colon cancer cells. In order to furth...

    Maoxi Liu, Kunli Du, Bo Jiang, **ngye Wu in Pathology & Oncology Research (2020)

  5. No Access

    Article

    Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway

    Hypoxia is a common feature of solid tumor, and is a direct stress that triggers apoptosis in many human cell types. As one of solid cancer, hypoxia exists in the whole course of colon cancer occurrence and pr...

    Maoxi Liu, Zhongxue Fu, **ngye Wu, Kunli Du, Shouru Zhang, Li Zeng in Tumor Biology (2016)

  6. No Access

    Article

    Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer

    The mammalian peroxiredoxin 2 (Prdx2) is a member of thiol-dependent antioxidant proteins and plays an important role in the progression of colorectal cancer (CRC). The aim of this study was to confirm the ro...

    Shouru Zhang, Zhongxue Fu, **lai Wei, **bao Guo, Maoxi Liu, Kunli Du in Medical Oncology (2014)

  7. No Access

    Article

    Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions

    Hypoxia is a common characteristic of solid tumors. Recent studies confirmed that phospholipase D2 (PLD2) plays significant roles in cancer progression. In this study, correlation between the expression of PLD...

    Maoxi Liu, Kunli Du, Zhongxue Fu, Shouru Zhang, **ngye Wu in Medical Oncology (2014)