13 Result(s)

Article

Decreased incidence of acute immune thrombocytopenia in children during the COVID-19 pandemic

Daisuke Harama, Kumiko Goi, Kinuko Saito… in International Journal of Hematology (2023)

Article

Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis

The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chro...

Minori Tamai, Shinichi Fujisawa, Thao T. T. Nguyen, Chiaki Komatsu… in Cancer Gene Therapy (2023)

Article

Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines

The genetic variants of the ARID5B gene have recently been reported to be associated with disease susceptibility and treatment outcome in childhood acute lymphoblastic leukemia (ALL). However, few studies have ex...

Minori Tamai, Meixian Huang, Keiko Kagami, Masako Abe… in Cancer Cell International (2020)

Article

T315I mutation of BCR-ABL1 into human Philadelphia chromosome-positive leukemia cell lines by homologous recombination using the CRISPR/Cas9 system

In many cancers, somatic mutations confer tumorigenesis and drug-resistance. The recently established clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is a potentially elegant app...

Minori Tamai, Takeshi Inukai, Satoru Kojika, Masako Abe, Keiko Kagami… in Scientific Reports (2018)

Article

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression

Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression. Known that CD44 has the specific bin...

Shin Kasai, Yoshiyuki Furuichi, Norie Ando, Keiko Kagami… in Cell Death & Disease (2017)

Article

Hepatocyte Growth Factor Protects Small Airway Epithelial Cells from Apoptosis Induced by Tumor Necrosis Factor-α or Oxidative Stress

Involvement of hepatocyte growth factor (HGF) in lung morphogenesis and regeneration has been established by in vitro and in vivo experiments in animals. In the present study, the protective activity of HGF again...

Michiyo Okada, Kanji Sugita, Takeshi Inukai, Kumiko Goi, Keiko Kagami… in Pediatric Research (2004)

Article

Transient Increase in CD45RO Expression on T Lymphocytes in Infected Newborns

Although infections are a significant cause of mortality and long-term morbidity of newborns, the early diagnosis of neonatal infections remains difficult. It has been shown recently that up-regulation of CD45...

Toru Tezuka, Kanji Sugita, Naoki Mizobe, Kumiko Goi, Naohiko Miyamoto… in Pediatric Research (1998)