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Article
Comparison of 3-nitrophenylhydrazine, O-benzyl hydroxylamine, and 2-picolylamine derivatizations for analysis of short-chain fatty acids through liquid chromatography coupled with tandem mass spectrometry
Short-chain fatty acids (SCFAs) are metabolites derived from gut microbiota and implicated in host homeostasis. Hence, the profiling SCFAs from biological samples plays an important role in revealing the inter...
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Article
Open AccessUplift modeling to identify patients who require extensive catheter ablation procedures among patients with persistent atrial fibrillation
Identifying patients who would benefit from extensive catheter ablation along with pulmonary vein isolation (PVI) among those with persistent atrial fibrillation (AF) has been a subject of controversy. The obj...
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Article
Initial multicenter clinical experience with the first-generation endoscopic guided laser balloon in Japan
Isolation of the pulmonary veins (PVs) is the golden standard for atrial fibrillation (AF) ablation. To achieve a permanent PV isolation, the endoscopic guided HeartLight laser balloon system was invented. We ...
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Article
Development of a useful single-reference HPLC method for therapeutic drug monitoring of phenytoin and carbamazepine in human plasma
A single reference high-performance liquid chromatographic (SR-HPLC) method was developed and validated for the therapeutic drug monitoring (TDM) of phenytoin (PHT) and carbamazepine (CBZ) in plasma from patie...
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Article
Sudden severe left ventricular assist device inflow cannula obstruction caused by huge thrombus after closure of mechanical aortic valve: case report
Thrombus formation is a troublesome and sometimes lethal complication occurring in patients with severe heart failure and supported by a left ventricular assist device (LVAD). Appropriate treatment for pump th...
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Article
Post-ablation left atrial function impacts long-term recurrence of atrial fibrillation after ablation
Left atrial (LA) function can help predict various cardiovascular events. Catheter ablation for atrial fibrillation (AF) modifies baseline LA function through the maintenance of sinus rhythm and myocardial inj...
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Article
Decrease in red cell distribution width as a useful predictor of success after catheter ablation for atrial fibrillation: a retrospective multi-center study
Red cell distribution width (RDW) is reportedly associated with cardiovascular events, including atrial fibrillation (AF). We investigated whether the RDW values were associated with the outcomes of catheter a...
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Article
Stable Isotope Labeling by Carbon-13 in Bacteria Culture for the Analysis of Residual Avermectin Using Stable Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry
This study describes the development of a new stable isotope labeling method by carbon-13 in bacteria culture (SILCB) for the analysis of residual antibiotics via liquid chromatography with tandem mass spectro...
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Article
Heat Loss Analysis of Flow Boiling Experiments Onboard International Space Station with Unclear Thermal Environmental Conditions (2nd Report: Liquid-vapor Two-phase Flow Conditions at Test Section Inlet)
This is the second report on the development of heat loss model for flow boiling experiments conducted onboard International Space Station (ISS). In the first paper (Inoue et al. 2021), a heat loss model was deve...
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Article
Open AccessA phase 1 study of crenigacestat (LY3039478), the Notch inhibitor, in Japanese patients with advanced solid tumors
Background This phase 1, single-center, nonrandomized, single-arm, open-label, dose-escalation study, evaluated the tolerability of crenigacestat, a γ-secretase inhibitor as an oral Notch inhibitor in Japanese pa...
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Article
Heat Loss Analysis of Flow Boiling Experiments Onboard International Space Station with Unclear Thermal Environmental Conditions (1st Report: Subcooled Liquid Flow Conditions at Test Section Inlet)
Two series of flow boiling experiments have been conducted onboard the International Space Station (ISS) as a part of the TPF (Two-Phase Flow) experiment promoted by JAXA during July 2017–March 2018, February ...
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Chapter
Electrical Biosensor Using Graphene Field-Effect Transistor and Small Receptor Molecules
Graphene is a two-dimensional nanocarbon material that exhibits unique physical properties. Graphene field-effect transistor (FET) has a strong potential for an electrical biosensor, because graphene FET trans...
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Article
Open AccessToxicological analysis of satratoxins, the main toxins in the mushroom Trichoderma cornu-damae, in human serum and mushroom samples by liquid chromatography–tandem mass spectrometry
Many poisoning cases involving the deadly toxic mushroom Trichoderma cornu-damae have been reported, but there are very few reports on toxicological analysis of the poisoning. In this study, a simple and sensitiv...
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Article
Correction to: Phase 1 dose-escalation study of a novel oral PI3K/mTOR dual inhibitor, LY3023414, in patients with cancer
The article Phase 1 dose-escalation study of a novel oral PI3K/mTOR dual inhibitor, LY3023414, in patients with cancer, written by Shunsuke Kondo, Masaomi Tajimi, Tomohiko Funai, Koichi Inoue, Hiroya Asou, Vin...
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Article
Open AccessPhase 1 dose-escalation study of a novel oral PI3K/mTOR dual inhibitor, LY3023414, in patients with cancer
LY3023414 is an oral, selective adenosine triphosphate-competitive inhibitor of class I phosphatidylinositol 3-kinase isoforms, mammalian target of rapamycin, and DNA-protein kinase in clinical development. We...
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Article
Screening Method for the Quality Evaluation of Cannabidiols in Water-based Products Using Liquid Chromatography Tandem Mass Spectrometry
A sensitive, useful and preliminary screening method was proposed to quantitate the containable cannabinoids most commonly included in mineral water and gummi candy products, specifically cannabidiol (CBD), ca...
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Article
Advances in Chromatographic Analysis of Cannabidiol (CBD)
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Article
Exploring Factors that Influence Collaborative Problem Solving Awareness in Science Education
This study designed a science course following collaborative problem solving (CPS) processes, and examined the effect on students’ CPS awareness. The Limnic Eruption CPS course was implemented using a Moodle syst...
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Article
Application of High-speed Countercurrent Chromatography for the Purification of High-purity Illudin S from Omphalotus japonicus
Illudin S from mushroom, such as Omphalotus japonicus and illudens, is a natural sesquiterpene analog with strong antitumor and antiviral activities. These illudins compounds are highly effective against various ...
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Article
Clinical experience of idarucizumab use in cases of cardiac tamponade under uninterrupted anticoagulation of dabigatran during catheter ablation of atrial fibrillation
Anticoagulants are prescribed for prevention of thromboembolic events (TE) of atrial fibrillation (AF), however, their effects have a negative impact on disastrous bleeding outcomes. Idarucizumab was developed...
