20 Result(s)
within
Klaus Pantel
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMaster corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2
While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered protein...
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Article
Open AccessEpCAM-positive circulating tumor cells and serum AFP levels predict outcome after curative resection of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has high recurrence rates exceeding 50% despite curative resection. The serum biomarker alpha-fetoprotein (AFP) is a well-known prognostic marker for HCC. EpCAM-positive circulat...
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Open AccessRegulation of bone homeostasis by MERTK and TYRO3
The fine equilibrium of bone homeostasis is maintained by bone-forming osteoblasts and bone-resorbing osteoclasts. Here, we show that TAM receptors MERTK and TYRO3 exert reciprocal effects in osteoblast biolog...
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Open AccessCopy number variations in primary tumor, serum and lymph node metastasis of bladder cancer patients treated with radical cystectomy
The aim of the present study was to analyze copy number variations (CNV) of multiple oncogenes and tumor suppressor genes in genomic DNA from primary tumor tissue, lymph node metastasis and cell-free DNA (cfDN...
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Open AccessAuthor Correction: Intraoperative detection of circulating tumor cells in pulmonary venous blood during metastasectomy for colorectal lung metastases
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessAuthor Correction: Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessEGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients
Although clinically relevant, the detection rates of EpCAM positive CTCs in non-small cell lung cancer (NSCLC) are surprisingly low. To find new clinically informative markers for CTC detection in NSCLC, the e...
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Open AccessThe prognostic relevance of urokinase-type plasminogen activator (uPA) in the blood of patients with metastatic breast cancer
In breast cancer (BC), elevated levels of urokinase-type plasminogen activator (uPA) in tumor tissue have been confirmed as a strong prognostic factor in level-of-evidence-1 studies. The aim of the present stu...
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Open AccessDevelopment and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer
Here we describe the establishment and characterization of an AR+, PSMA+, ERG+, PTEN−/−, CHD1+/− patient-derived xenograft (PDX) model termed ‘C5’, which has been developed from a 60 years old patient suffering f...
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Open AccessAutologous cell lines from circulating colon cancer cells captured from sequential liquid biopsies as model to study therapy-driven tumor changes
Circulating tumor cells (CTCs) are important clinical indicators for prognosis and treatment efficacy. However, CTC investigation is hampered by their low number, making the establishment of permanent CTC line...
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Article
Open AccessDifferent signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients
Loading of microRNAs (miRNAs) into exosomes that are involved in cellular communication is a selective process. The current study investigates whether the enrichment of miRNAs in exosomes reflects the pathogen...
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Open AccessIntraoperative detection of circulating tumor cells in pulmonary venous blood during metastasectomy for colorectal lung metastases
Circulating tumor cells (CTC) have been studied extensively in various tumor types and are a well-established prognosticator in colorectal cancer (CRC). This is the first study to isolate CTC directly from the...
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Article
Open AccessEvaluation of serum epidermal growth factor receptor (EGFR) in correlation to circulating tumor cells in patients with metastatic breast cancer
Overexpression of epidermal growth factor receptor in breast cancer is associated with estrogen receptor negativity, higher histological grade and larger tumors. The aim of the present study was to evaluate th...
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Open AccessCirculating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement...
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Article
Open AccessCatch and Release: rare cell analysis from a functionalised medical wire
Enumeration and especially molecular characterization of circulating tumour cells (CTCs) holds great promise for cancer management. We tested a modified type of an in vivo enrichment device (Catch&Release) for it...
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Open AccessImproved detection of circulating tumor cells in non-metastatic high-risk prostate cancer patients
The relevance of blood-based assays to monitor minimal residual disease (MRD) in non-metastatic prostate cancer (PCa) remains unclear. Proving that clinically relevant circulating tumor cells (CTCs) can be det...
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Open AccessChronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen
Chronic UVB-exposure and declined estradiol production after menopause represent important factors leading to extrinsic and intrinsic aging, respectively. Remodeling of the extracellular matrix (ECM) plays a c...
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Open AccessCharacterization of different CTC subpopulations in non-small cell lung cancer
Circulating tumour cells (CTCs) serve as valuable biomarkers. However, EpCAM positive CTCs are less frequently detected in NSCLC patients compared to other epithelial tumours. First, EpCAM protein expression w...
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Open AccessHeterogeneity of miR-10b expression in circulating tumor cells
Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be us...
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Article
Open AccessA Versatile Microarray Platform for Capturing Rare Cells
Analyses of rare events occurring at extremely low frequencies in body fluids are still challenging. We established a versatile microarray-based platform able to capture single target cells from large backgrou...
