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Open AccessCommentary on my personal experience of patient and public involvement in the TOPSY trial
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Open AccessTheoretical and practical development of the TOPSY self-management intervention for women who use a vaginal pessary for pelvic organ prolapse
Pelvic organ prolapse (POP) is a common condition in women, where the downward descent of pelvic organs into the vagina causes symptoms which impacts quality of life. Vaginal pessaries offer an effective alter...
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Open AccessClinical and cost-effectiveness of vaginal pessary self-management compared to clinic-based care for pelvic organ prolapse: protocol for the TOPSY randomised controlled trial
Pelvic organ prolapse (or prolapse) is a common condition in women where the pelvic organs (bladder, bowel or womb) descend into the vagina and cause distressing symptoms that adversely affect quality of life....
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Open AccessThe TOPSY pessary self-management intervention for pelvic organ prolapse: a study protocol for the process evaluation
Process evaluations have become a valued component, alongside clinical trials, of the wider evaluation of complex health interventions. They support understanding of implementation, and fidelity, related to th...
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Article
Open AccessIt is unprecedented: trial management during the COVID-19 pandemic and beyond
The COVID-19 pandemic has presented unique challenges for the clinical trial community, both in the rapid establishment of COVID-19 clinical trials and many existing non-COVID-19 studies either being temporari...
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Article
Open AccessUsing systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project
Data collection consumes a large proportion of clinical trial resources. Each data item requires time and effort for collection, processing and quality control procedures. In general, more data equals a heavie...
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Article
Open AccessWhere do we go from here? – Opportunities and barriers to the career development of trial managers: a survey of UK-based trial management professionals
Clinical trials commonly have a dedicated trial manager and effective trial management is essential to the successful delivery of high-quality trials. Trial managers have diverse experience and currently there...
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Open AccessAbdominal massage for neurogenic bowel dysfunction in people with multiple sclerosis (AMBER — Abdominal Massage for Bowel Dysfunction Effectiveness Research): study protocol for a randomised controlled trial
Multiple sclerosis (MS) is a life-long condition primarily affecting younger adults. Neurogenic bowel dysfunction (NBD) occurs in 50–80% of these patients and is the term used to describe constipation and faec...
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Article
Patient-Reported Outcomes in Rheumatoid Arthritis
Background: The questionnaires used in clinical research have often been developed and validated using paper, and in such cases it is necessary to show that the electronic versions are equivalent...