Skip to main content

4 Result(s)

within Kirk M. Brown Remove this filter

and

  1. Article

    Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

    Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2′-O-hexadecy...

    Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas… in Nature Biotechnology (2022)

    Download PDF (3847 KB) View Article

  2. No Access

    Article

    The measurement of CSF flow through the aqueduct in normal and hydrocephalic children: from where does it come, to where does it go?

    Despite 100 years of study, the theories of cerebrospinal fluid (CSF) formation and absorption remain controversial. Measuring CSF flow through the aqueduct using magnetic resonance imaging (MRI) provides a un...

    Grant A. Bateman, Kirk M. Brown in Child's Nervous System (2012)

  3. No Access

    Article

    Target accessibility dictates the potency of human RISC

    In this report, we examined the effect of increased target site access on activated human RNA-induced silencing complex (RISC*) catalysis. Kinetic studies revealed that siRNA-programmed RISC* cleaved target RNA w...

    Kirk M Brown, Chia-ying Chu, Tariq M Rana in Nature Structural & Molecular Biology (2005)

  4. No Access

    Article

    Specific and potent RNAi in the nucleus of human cells

    RNA interference (RNAi) has become a research tool to control gene expression in various organisms and holds potential as a new therapeutic strategy. The mechanism of small interfering RNA (siRNA)-mediated RNA...

    G Brett Robb, Kirk M Brown, Jaspreet Khurana… in Nature Structural & Molecular Biology (2005)