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Article
Open AccessA sco** review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?
The literature regarding the global cerebral blood flow (CBF) in idiopathic intracranial hypertension (IIH) is divergent leading to skepticism about the significance of blood flow to the disease’s underlying p...
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Article
Open AccessDilatation of the bridging cerebral cortical veins in childhood hydrocephalus suggests a malfunction of venous impedance pum**
Dogs with a naturally occurring form of hydrocephalus have an elevated transmural venous pressure leading to cortical vein dilatation. The purpose of this study is to discover if there is vein dilatation in ch...
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Article
Open AccessComparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?
There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. T...
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Article
Open AccessA comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?
It has been suggested there is a chronic neurodegenerative disorder, underlying the pathophysiology of multiple sclerosis (MS), which is distinct from the more obvious immune-mediated attack on the white matte...
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Article
Open AccessCerebrospinal fluid absorption block at the vertex in chronic hydrocephalus: obstructed arachnoid granulations or elevated venous pressure?
The lack of absorption of CSF at the vertex in chronic hydrocephalus has been ascribed to an elevation in the arachnoid granulation outflow resistance (Rout). The CSF infusion studies measuring Rout are dependent...
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Article
Open AccessAn olfactory ‘stress test’ may detect preclinical Alzheimer’s disease
The olfactory bulb (OB) receives extensive cholinergic input from the basal forebrain and is affected very early in Alzheimer’s disease (AD). We speculated that an olfactory ‘stress test’ (OST), targeting the ...
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Article
The measurement of CSF flow through the aqueduct in normal and hydrocephalic children: from where does it come, to where does it go?
Despite 100 years of study, the theories of cerebrospinal fluid (CSF) formation and absorption remain controversial. Measuring CSF flow through the aqueduct using magnetic resonance imaging (MRI) provides a un...
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Article
Correction to “External hydrocephalus in infants: six cases with MR venogram and flow quantification correlation”
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Article
External hydrocephalus in infants: six cases with MR venogram and flow quantification correlation
The cause of external hydrocephalus in infants is largely unknown. However, familial macrocephaly and delayed maturation of the arachnoid granulations are thought to play a part in the idiopathic cases. Second...
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Article
The correlations between a proposed pathogenesis of syringomyelia and normal pressure hydrocephalus
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Article
The venous manifestations of pulse wave encephalopathy: windkessel dysfunction in normal aging and senile dementia
Cerebral arterial, venous and cerebrospinal fluid (CSF) pulsations are closely coupled and this produces pulsation dampening or the windkessel effect. Normal pressure hydrocephalus is a manifestation of the br...
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Article
Extending the hydrodynamic hypothesis in chronic hydrocephalus
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Article
The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co-morbidity with other forms of dementia be excluded?
Variable results are obtained from the treatment of normal pressure hydrocephalus (NPH) by shunt insertion. There is a high correlation between NPH and the pathology of Alzheimer’s disease (AD) on brain biops...
