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Article
Structural insights into the stereochemistry of the cyclooxygenase reaction
Cyclooxygenases are bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, thromboxanes and other eicosanoids1,2,3. The two known cyclooxygenases isoforms share a high deg...
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Article
Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography
We tested whether the translocator protein (TSPO)-targeted positron emission tomography (PET) tracer, N-acetyl-N-(2-[11C]methoxybenzyl)-2-phenoxy-5-pyridinamine ([11C]PBR28), could distinguish macrophage dominant...