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    Article

    Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography

    We tested whether the translocator protein (TSPO)-targeted positron emission tomography (PET) tracer, N-acetyl-N-(2-[11C]methoxybenzyl)-2-phenoxy-5-pyridinamine ([11C]PBR28), could distinguish macrophage dominant...

    Delphine L. Chen, Eugene Agapov, Kangyun Wu… in Molecular Imaging and Biology (2021)

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    Article

    Structural insights into the stereochemistry of the cyclooxygenase reaction

    Cyclooxygenases are bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, thromboxanes and other eicosanoids1,2,3. The two known cyclooxygenases isoforms share a high deg...

    James R. Kiefer, Jennifer L. Pawlitz, Kirby T. Moreland, Roderick A. Stegeman… in Nature (2000)