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  1. No Access

    Article

    Prostate-specific membrane antigen-positron emission tomography (PSMA-PET) of prostate cancer: current and emerging applications

    Prostate-specific membrane antigen-positron emission tomography (PSMA-PET) is transforming the management of patients with prostate cancer. In appropriately selected patients, PSMA-PET offers superior sensitiv...

    Shamus Moran, Heather H. Cheng, Emily Weg, Eric H. Kim… in Abdominal Radiology (2024)

  2. No Access

    Article

    Artificial intelligence in immunotherapy PET/SPECT imaging

    Immunotherapy has dramatically altered the therapeutic landscape for oncology, but more research is needed to identify patients who are likely to achieve durable clinical benefit and those who may develop unac...

    Jeremy P. McGale, Delphine L. Chen, Stefano Trebeschi… in European Radiology (2024)

  3. Article

    Open Access

    Pilot Study: PARP1 Imaging in Advanced Prostate Cancer

    PARP inhibitor (PARPi) therapy is approved for patients with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) genomic aberrations. However, only a fraction of p...

    Farrokh Dehdashti, Melissa A. Reimers, Kooresh I. Shoghi… in Molecular Imaging and Biology (2022)

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    Article

    Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography

    We tested whether the translocator protein (TSPO)-targeted positron emission tomography (PET) tracer, N-acetyl-N-(2-[11C]methoxybenzyl)-2-phenoxy-5-pyridinamine ([11C]PBR28), could distinguish macrophage dominant...

    Delphine L. Chen, Eugene Agapov, Kangyun Wu… in Molecular Imaging and Biology (2021)

  5. Article

    Open Access

    Glypican-3 targeted delivery of 89Zr and 90Y as a theranostic radionuclide platform for hepatocellular carcinoma

    Glypican-3 (GPC3) is a tumor associated antigen expressed by hepatocellular carcinoma (HCC) cells. This preclinical study evaluated the efficacy of a theranostic platform using a GPC3-targeting antibody αGPC3 ...

    Kevin P. Labadie, Andrew D. Ludwig, Adrienne L. Lehnert… in Scientific Reports (2021)

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  6. No Access

    Chapter

    Clinical Imaging

    At the present time clinically available imaging modalities, both anatomical and functional, rely primarily on the host immune response to diagnose infection. These methods, though useful, are not specific for...

    Delphine L. Chen, Philip M. Scherer, Christopher J. Palestro in Imaging Infections (2017)

  7. No Access

    Article

    Imaging Caspase-3 Activation as a Marker of Apoptosis-Targeted Treatment Response in Cancer

    We tested whether positron emission tomography (PET) with the caspase-3-targeted isatin analog [18F]WC-4-116 could image caspase-3 activation in response to an apoptosis-inducing anticancer therapy.

    Delphine L. Chen, Jacquelyn T. Engle, Elizabeth A. Griffin… in Molecular Imaging and Biology (2015)

  8. Article

    Multimodality molecular imaging of the lung

    Lung diseases cause significant morbidity and mortality and lead to high healthcare utilization. However, few lung disease-specific biomarkers are available to accurately monitor disease activity for the purpo...

    Delphine L. Chen, Paul E. Kinahan in Clinical and Translational Imaging (2014)

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