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  1. No Access

    Article

    Direct enzymatic sequencing of 5-methylcytosine at single-base resolution

    5-methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The ideal method for 5mC localization would be both nondestructive of DNA and direct, without requiring inference based on de...

    Tong Wang, Johanna M. Fowler, Laura Liu, Christian E. Loo… in Nature Chemical Biology (2023)

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    Article

    Controllable genome editing with split-engineered base editors

    DNA deaminase enzymes play key roles in immunity and have recently been harnessed for their biotechnological applications. In base editors (BEs), the combination of DNA deaminase mutator activity with CRISPR–C...

    Kiara N. Berríos, Niklaus H. Evitt, Rachel A. DeWeerd, Diqiu Ren… in Nature Chemical Biology (2021)