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Article
Impact of presentation at conference with timed release of academic publication
Fast-tracking publication of original research to coincide with a conference presentation (“coordinated publication”) is a mechanism of rapidly disseminating new data. How often this occurs, whether its freque...
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Article
Open AccessRecurrent repeat expansions in human cancer genomes
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to cause more than 50 diseases1,2. However, repeat expansions are often not explored beyond neurological and neurodegenerative ...
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Article
Open AccessHighly efficacious and safe neutralizing DNA aptamer of SARS-CoV-2 as an emerging therapy for COVID-19 disease
The paucity of SARS-CoV-2-specific virulence factors has greatly hampered the therapeutic management of patients with COVID-19 disease. Although available vaccines and approved therapies have shown tremendous ...
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Article
Open AccessLanguage models can learn complex molecular distributions
Deep generative models of molecules have grown immensely in popularity, trained on relevant datasets, these models are used to search through chemical space. The downstream utility of generative models for the...
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Open AccessDeep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders
Despite strong evidence of heritability and growing discovery of genetic markers for major mental illness, little is known about how gene expression in the brain differs across psychiatric diagnoses, or how kn...
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Open AccessPolygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder
Bipolar disorder is often comorbid with anxiety, which is itself associated with poorer clinical outcomes, including suicide. A better etiologic understanding of this comorbidity could inform diagnosis and tre...
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Article
Open AccessPharmacological Profiling of Purified Human Stem Cell-Derived and Primary Mouse Motor Neurons
Directed differentiation of human pluripotent stem cells (hPSCs) has enabled the generation of specific neuronal subtypes that approximate the intended primary mammalian cells on both the RNA and protein level...
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Article
Open AccessDe-implementation of low value castration for men with prostate cancer: protocol for a theory-based, mixed methods approach to minimizing low value androgen deprivation therapy (DeADT)
Men with prostate cancer are often castrated with long-acting injectable drugs termed androgen deprivation therapy (ADT). Although many benefit, ADT is also used in patients with little or nothing to gain. The...
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Article
The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia
Parkinson's disease (PD) is recognized as the most common neurodegenerative movement disorder and results in debilitating motor deficits. The accumulation and spread of neurotoxic synuclein aggregates in the f...
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Open AccessOncogenes and tumor suppressor genes: comparative genomics and network perspectives
Defective tumor suppressor genes (TSGs) and hyperactive oncogenes (OCGs) heavily contribute to cell proliferation and apoptosis during cancer development through genetic variations such as somatic mutations an...
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Open AccessA comparative study of disease genes and drug targets in the human protein interactome
Disease genes cause or contribute genetically to the development of the most complex diseases. Drugs are the major approaches to treat the complex disease through interacting with their targets. Thus, drug tar...
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Article
Innovation diffusion in global contexts: determinants of post-adoption digital transformation of European companies
Grounded in the diffusion of innovation theory and the technology–organization–environment framework, we develop an integrative model to study the determinants of post-adoption stages of innovation diffusion, ...
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Article
Electronic business adoption by European firms: a cross-country assessment of the facilitators and inhibitors
In this study, we developed a conceptual model for studying the adoption of electronic business (e-business or EB) at the firm level, incorporating six adoption facilitators and inhibitors, based on the techno...
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Strategic exercise of real options: Investment decisions in technological systems
Viewing investment projects in new technologies as real options, this paper studies the effects of endogenous competition and asymmetric information on the strategic exercise of real options. We first develop ...
