22 Result(s)
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Article
Psychometric utility of the international HIV dementia scale and Montreal Cognitive Assessment in HIV-associated asymptomatic neurocognitive impairment
There is a growing need for brief screening measures for HIV Associated Neurocognitive Disorders (HAND). We compared two commonly used measures (the Montreal Cognitive Assessment [MoCA] and the International H...
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Article
Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda
We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reporte...
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Article
Limited correlation between systemic biomarkers and neurocognitive performance before and during HIV treatment
The AIDS Clinical Trials Group (ACTG) study A5303 investigated the associations between neuropsychological performance (NP) and inflammatory biomarkers in HIV-infected participants. Fifteen NP tests were admin...
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Article
Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda
Considerable heterogeneity exists in patterns of neurocognitive change in people with HIV (PWH). We examined heterogeneity in neurocognitive change trajectories from HIV diagnosis to 1–2 years post-antiretrovi...
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Article
Open AccessSimilar neurocognitive outcomes after 48 weeks in HIV-1-infected participants randomized to continue tenofovir/emtricitabine + atazanavir/ritonavir or simplify to abacavir/lamivudine + atazanavir
Human immunodeficiency virus (HIV)-associated neurocognitive disorders can persist in many patients despite achieving viral suppression while on antiretroviral therapy (ART). Neurocognitive function over 48 we...
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Reference Work Entry In depth
Global NeuroAIDS
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Reference Work Entry In depth
Neurotoxic Consequences of Antiretroviral Therapies
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Article
Cerebrospinal fluid biomarkers and HIV-associated neurocognitive disorders in HIV-infected individuals in Rakai, Uganda
In the USA, increased cerebrospinal fluid (CSF) inflammatory cytokines have been observed in antiretroviral therapy (ART)-naive, HIV-seropositive individuals with HIV-associated neurocognitive disorder (HAND)....
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Living Reference Work Entry In depth
Global NeuroAIDS
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Article
Longitudinal Characterization of Depression and Mood States Beginning in Primary HIV Infection
Though depression is known to frequently afflict those with chronic HIV, mood during the early course of HIV is not well characterized. In a prospective study we assessed mood during primary HIV infection [pri...
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Living Reference Work Entry In depth
Neurotoxic Consequences of Antiretroviral Therapies
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Article
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy
Emerging evidence suggests that CNS injury and neurocognitive impairment persist in the setting of chronic HIV infection and combination antiretroviral therapy (CART). Yet, whether neurological injury can prog...
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Article
Longitudinal neuropsychological test performance among HIV seropositive individuals in Uganda
This study was conducted to evaluate longitudinal neuropsychological testing performance over a 12-month period among HIV + individuals, and to evaluate the impact of antiretroviral therapy (ART) initiation on...
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Article
Global NeuroAIDS Roundtable
In May 2012, the Division of AIDS Research at the National Institute of Mental Health (NIMH) organized the “Global NeuroAIDS Roundtable” in conjunction with the 11th International Symposium on Neurovirology an...
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Article
Antiretroviral neurotoxicity
Combination antiretroviral therapy (CART) has proven to effectively suppress systemic HIV burden, however, poor penetration into the central nervous system (CNS) provides incomplete protection. Although the se...
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Article
A multinational study of neurological performance in antiretroviral therapy-naïve HIV-1-infected persons in diverse resource-constrained settings
Little is known about how the prevalence and incidence of neurological disease in HIV-infected patients in resource-limited settings. We present an analysis of neurological and neurocognitive function in antir...
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Article
Protein changes in CSF of HIV-infected patients: evidence for loss of neuroprotection
To begin to unravel the complexity of HIV-associated changes in the brain, broader, multifaceted analyses of cerebrospinal fluid (CSF) are needed that examine a wide range of proteins reflecting different func...
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Article
NeuroAIDS in Africa
In July 2009, the Center for Mental Health Research on AIDS at the National Institute of Mental Health organized and supported the meeting “NeuroAIDS in Africa.” This meeting was held in Cape Town, South Afric...
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Article
NeuroAIDS in the Asia Pacific Region
Over 8.3 million people living in the Asia Pacific region are human immunodeficiency virus (HIV) positive and up to 40% of these individuals have had prior acquired immunodeficiency syndrome (AIDS) illnesses. ...
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Article
Second assessment of NeuroAIDS in Africa
In July of 2006, the National Institute of Mental Health (NIMH) Center for Mental Health Research on AIDS (CMHRA) sponsored the second conference on the Assessment of NeuroAIDS in Africa, which was held in Aru...
