Global NeuroAIDS

  • Living reference work entry
  • Latest version View entry history
  • First Online:
Encyclopedia of AIDS

Definition

The term NeuroAIDS encompasses all the neurological complications associated with HIV. This includes diseases that primarily result from direct infection of the CNS with HIV (HIV-associated neurocognitive disorders [HAND]), secondary conditions resulting either from the effects of associated immunocompromise (neurologic opportunistic infections or tumors) or the effects of treatment (such as the immune reconstitution syndrome [IRIS]) as well as other diseases that could be influenced but not caused by HIV (e.g., stroke).

Types of HIV-Associated Neurological Syndromes

  • Primary HIV neurological diseases

    • HIV-associated neurocognitive disorders (HAND)

      • Asymptomatic neurocognitive impairment (ANI)

      • Mild neurocognitive disorder (MND)

      • HIV-associated dementia (HAD)

    • Aseptic meningitis

    • HIV-associated myelopathy

    • HIV-associated peripheral neuropathies

      • Distal symmetric polyneuropathy (DSP)

      • Inflammatory demyelinating polyneuropathy (IDPN)

      ...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE. Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007;30:1789–99.

    Article  Google Scholar 

  • Asselman V, Thienemann F, Pepper DJ, Boulle A, Wilkinson RJ, Meintjes G, Marais S. Central nervous system disorders after starting antiretroviral therapy in South Africa. AIDS. 2010;24:2871–6.

    Article  PubMed  Google Scholar 

  • Brew BJ, Chan P. Update on HIV dementia and HIV-associated neurocognitive disorders. Curr Neurol Neurosci Rep. 2014;14:1–7.

    Article  CAS  Google Scholar 

  • Heaton RK, Clifford DB, Franklin DR, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2010;75:2087–2096.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hogan C, Wilkins E. Neurological complications in HIV. Clin Med. 2011;11:571–5.

    Article  PubMed  Google Scholar 

  • Joseph J, Achim CL, Boivin MJ, et al. Global NeuroAIDS Roundtable. Journal of NeuroVirology. 2013;19(1):1–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kranick SM, Nath A. Neurologic complications of HIV-1 infection and its treatment in the era of antiretroviral therapy. CONTINUUM Lifelong Learn Neurol. 2012;18:1319–37.

    Article  Google Scholar 

  • Mirza A, Rathore MH. Human immunodeficiency virus and the central nervous system. Semin Pediatr Neurol. 2012;19:119–23.

    Article  PubMed  Google Scholar 

  • Ovbiagele B, Nath A. Increasing incidence of ischemic stroke in patients with HIV infection. Neurology. 2011;76:444–50.

    Article  PubMed Central  PubMed  Google Scholar 

  • Previti MC, Marra CM. Spinal cord disease. In: Gendelman HE, Grant I, Everall IP, Fox HS, Gelbard HA, Lipton SA, Swindels S, editors. The neurology of AIDS. New York: Oxford University Press; 2012. p. 546–50.

    Google Scholar 

  • Robertson K, Liner J, Hakim J, Sankalé JL, Grant I, Letendre S, Clifford D, Diop A, Jaye A, Kanmogne G, Njamnshi A, Langford TD, Weyessa T, Wood C, Banda M, Hosseinipour M, Sacktor N, Nakasuja N, Bangirana P, Paul R, Joska JA, Wong J, Boivin M, Holding P, Kammerer B, Van Rie A, Ive P, Nath A, Lawler K, Adebamowo C, Royal W, Joseph J. NeuroAIDS in Africa. J NeuroVirol. 2010;16:189–202.

    Article  PubMed Central  PubMed  Google Scholar 

  • Sacktor N, Nakasujja N, Robertson K, Clifford DB. HIV-associated cognitive impairment in sub-Saharan Africa- the potential effect of clade diversity. Nat Clin Pract Neurol. 2007;3:436–43.

    Article  PubMed  Google Scholar 

  • Sacktor N, Robertson K. Evolving clinical phenotypes in HIV-associated neurocognitive disorders. Current Opinion in HIV and AIDS. 2014;9(6):517–520.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Schütz SG, Robinson-Papp J. HIV-related neuropathy: current perspectives. HIV AIDS (Auckl). 2013;11:243–51.

    Google Scholar 

  • Shapshak P, Kangueane P, Fujimura RK, Commins D, Chiappelli F, Singer E, Levine AJ, Minagar A, Novembre FJ, Somboonwit C, Nath A, Sinnott JT. Editorial neuroAIDS review. AIDS. 2011;25:123–41.

    Article  PubMed Central  PubMed  Google Scholar 

  • Spudich S, González-Scarano F. HIV-1-Related central nervous system disease: current issues in pathogenesis, diagnosis, and treatment. Cold Spring Harb Perspect Med. 2012;2:a007120.

    Article  PubMed Central  PubMed  Google Scholar 

  • Tan IL, Smith BR, von Geldern G, Mateen FJ, McArthur JC. HIV-associated opportunistic infections of the CNS. Lancet Neurol. 2012;11:605–17.

    Article  PubMed  Google Scholar 

  • UNAIDS. Global report: UNAIDS report on the global AIDS epidemic. Geneva: Joint United Nations Programme on HIV/AIDS; 2013.

    Google Scholar 

Download references

Acknowledgments

Research training of Dr. Bibilola Oladeji was supported by the Fogarty International Center of the National Institutes of Health under Award Number D43TW009608. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bibilola D. Oladeji .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this entry

Cite this entry

Oladeji, B.D., Yosief, S., Robertson, K. (2015). Global NeuroAIDS. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_216-2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_216-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Global NeuroAIDS
    Published:
    31 October 2015

    DOI: https://doi.org/10.1007/978-1-4614-9610-6_216-2

  2. Original

    Global NeuroAIDS
    Published:
    19 January 2015

    DOI: https://doi.org/10.1007/978-1-4614-9610-6_216-1

Navigation